Newly Designed Quinazolinone Derivatives as Novel Tyrosinase Inhibitor: Synthesis, Inhibitory Activity, and Mechanism

We synthesized a series of quinazolinone derivates as tyrosinase inhibitors and evaluated their inhibition constants. We synthesized 2-(2,6-dimethylhepta-1,5-dien-1-yl)quinazolin-4(3H)-one (Q1) from the natural citral. The concentration, which led to 50% activity loss of Q1, was 103 ± 2 μM (IC(50) =...

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Detalles Bibliográficos
Autores principales: Huang, Yaru, Yang, Jiefang, Chi, Yunyang, Gong, Chun, Yang, Haikuan, Zeng, Fanxin, Gao, Fang, Hua, Xiaoju, Wang, Zongde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457556/
https://www.ncbi.nlm.nih.gov/pubmed/36080324
http://dx.doi.org/10.3390/molecules27175558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457556/
https://www.ncbi.nlm.nih.gov/pubmed/36080324
http://dx.doi.org/10.3390/molecules27175558

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