Nucleation of the destruction complex on the centrosome accelerates degradation of β-catenin and regulates Wnt signal transmission

Wnt signal transduction is controlled by the destruction complex (DC), a condensate comprising scaffold proteins and kinases that regulate β-catenin stability. Overexpressed DC scaffolds undergo liquid–liquid phase separation (LLPS), but DC mesoscale organization at endogenous expression levels and...

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Detalles Bibliográficos
Autores principales: Lach, Ryan S., Qiu, Chongxu, Kajbaf, Erfan Zeyaei, Baxter, Naomi, Han, Dasol, Wang, Alex, Lock, Hannah, Chirikian, Orlando, Pruitt, Beth, Wilson, Maxwell Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457612/
https://www.ncbi.nlm.nih.gov/pubmed/36037369
http://dx.doi.org/10.1073/pnas.2204688119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457612/
https://www.ncbi.nlm.nih.gov/pubmed/36037369
http://dx.doi.org/10.1073/pnas.2204688119

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