Plumbagin Suppresses Breast Cancer Progression by Downregulating HIF-1α Expression via a PI3K/Akt/mTOR Independent Pathway under Hypoxic Condition

Hypoxia-inducible factor-1α (HIF-1α) is a major transcriptional regulator that plays a crucial role in the hypoxic response of rapidly growing tumors. Overexpression of HIF-1α has been associated with breast cancer metastasis and poor clinical prognosis. Plumbagin, the main phytochemical from Plumba...

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Detalles Bibliográficos
Autores principales: Jampasri, Supawan, Reabroi, Somrudee, Tungmunnithum, Duangjai, Parichatikanond, Warisara, Pinthong, Darawan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457614/
https://www.ncbi.nlm.nih.gov/pubmed/36080483
http://dx.doi.org/10.3390/molecules27175716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457614/
https://www.ncbi.nlm.nih.gov/pubmed/36080483
http://dx.doi.org/10.3390/molecules27175716

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