Synthesis of Sulfonamides Incorporating Piperidinyl-Hydrazidoureido and Piperidinyl-Hydrazidothioureido Moieties and Their Carbonic Anhydrase I, II, IX and XII Inhibitory Activity

Here we report a small library of hydrazinocarbonyl-ureido and thioureido benzenesulfonamide derivatives, designed and synthesized as potent and selective human carbonic anhydrase inhibitors (hCAIs). The synthesized compounds were evaluated against isoforms hCA I, II, IX and XII using acetazolamide...

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Detalles Bibliográficos
Autores principales: Moi, Davide, Deplano, Alessandro, Angeli, Andrea, Balboni, Gianfranco, Supuran, Claudiu T., Onnis, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457746/
https://www.ncbi.nlm.nih.gov/pubmed/36080139
http://dx.doi.org/10.3390/molecules27175370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457746/
https://www.ncbi.nlm.nih.gov/pubmed/36080139
http://dx.doi.org/10.3390/molecules27175370

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