Mechanical Properties and Antibacterial Effect on Mono-Strain of Streptococcus mutans of Orthodontic Cements Reinforced with Chlorhexidine-Modified Nanotubes

Recently, several studies have introduced nanotechnology into the area of dental materials with the aim of improving their properties. The objective of this study is to determine the antibacterial and mechanical properties of type I glass ionomers reinforced with halloysite nanotubes modified with 2...

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Autores principales: Salmerón-Valdés, Elias Nahum, Cruz-Mondragón, Ana Cecilia, Toral-Rizo, Víctor Hugo, Jiménez-Rojas, Leticia Verónica, Correa-Prado, Rodrigo, Lara-Carrillo, Edith, Morales-Valenzuela, Adriana Alejandra, Scougall-Vilchis, Rogelio José, López-Flores, Alejandra Itzel, Hoz-Rodriguez, Lia, Velásquez-Enríquez, Ulises
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457761/
https://www.ncbi.nlm.nih.gov/pubmed/36079929
http://dx.doi.org/10.3390/nano12172891
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author Salmerón-Valdés, Elias Nahum
Cruz-Mondragón, Ana Cecilia
Toral-Rizo, Víctor Hugo
Jiménez-Rojas, Leticia Verónica
Correa-Prado, Rodrigo
Lara-Carrillo, Edith
Morales-Valenzuela, Adriana Alejandra
Scougall-Vilchis, Rogelio José
López-Flores, Alejandra Itzel
Hoz-Rodriguez, Lia
Velásquez-Enríquez, Ulises
author_facet Salmerón-Valdés, Elias Nahum
Cruz-Mondragón, Ana Cecilia
Toral-Rizo, Víctor Hugo
Jiménez-Rojas, Leticia Verónica
Correa-Prado, Rodrigo
Lara-Carrillo, Edith
Morales-Valenzuela, Adriana Alejandra
Scougall-Vilchis, Rogelio José
López-Flores, Alejandra Itzel
Hoz-Rodriguez, Lia
Velásquez-Enríquez, Ulises
author_sort Salmerón-Valdés, Elias Nahum
collection PubMed
description Recently, several studies have introduced nanotechnology into the area of dental materials with the aim of improving their properties. The objective of this study is to determine the antibacterial and mechanical properties of type I glass ionomers reinforced with halloysite nanotubes modified with 2% chlorhexidine at concentrations of 5% and 10% relative to the total weight of the powder used to construct each sample. Regarding antibacterial effect, 200 samples were established and distributed into four experimental groups and six control groups (4 +ve and 2 −ve), with 20 samples each. The mechanical properties were evaluated in 270 samples, assessing microhardness (30 samples), compressive strength (120 samples), and setting time (120 samples). The groups were characterized by scanning electron microscopy and Fourier transform infrared spectroscopy, and the antibacterial activity of the ionomers was evaluated on Streptococcus mutans for 24 h. The control and positive control groups showed no antibacterial effect, while the experimental group with 5% concentration showed a zone of growth inhibition between 11.35 mm and 11.45 mm, and the group with 10% concentration showed a zone of growth inhibition between 12.50 mm and 13.20 mm. Statistical differences were observed between the experimental groups with 5% and 10% nanotubes. Regarding the mechanical properties, microhardness, and setting time, no statistical difference was found when compared with control groups, while compressive strength showed higher significant values, with ionomers modified with 10% concentration of nanotubes resulting in better compressive strength values. The incorporation of nanotubes at concentrations of 5% and 10% effectively inhibited the presence of S. mutans, particularly when the dose–response relationship was taken into account, with the advantage of maintaining and improving their mechanical properties.
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spelling pubmed-94577612022-09-09 Mechanical Properties and Antibacterial Effect on Mono-Strain of Streptococcus mutans of Orthodontic Cements Reinforced with Chlorhexidine-Modified Nanotubes Salmerón-Valdés, Elias Nahum Cruz-Mondragón, Ana Cecilia Toral-Rizo, Víctor Hugo Jiménez-Rojas, Leticia Verónica Correa-Prado, Rodrigo Lara-Carrillo, Edith Morales-Valenzuela, Adriana Alejandra Scougall-Vilchis, Rogelio José López-Flores, Alejandra Itzel Hoz-Rodriguez, Lia Velásquez-Enríquez, Ulises Nanomaterials (Basel) Article Recently, several studies have introduced nanotechnology into the area of dental materials with the aim of improving their properties. The objective of this study is to determine the antibacterial and mechanical properties of type I glass ionomers reinforced with halloysite nanotubes modified with 2% chlorhexidine at concentrations of 5% and 10% relative to the total weight of the powder used to construct each sample. Regarding antibacterial effect, 200 samples were established and distributed into four experimental groups and six control groups (4 +ve and 2 −ve), with 20 samples each. The mechanical properties were evaluated in 270 samples, assessing microhardness (30 samples), compressive strength (120 samples), and setting time (120 samples). The groups were characterized by scanning electron microscopy and Fourier transform infrared spectroscopy, and the antibacterial activity of the ionomers was evaluated on Streptococcus mutans for 24 h. The control and positive control groups showed no antibacterial effect, while the experimental group with 5% concentration showed a zone of growth inhibition between 11.35 mm and 11.45 mm, and the group with 10% concentration showed a zone of growth inhibition between 12.50 mm and 13.20 mm. Statistical differences were observed between the experimental groups with 5% and 10% nanotubes. Regarding the mechanical properties, microhardness, and setting time, no statistical difference was found when compared with control groups, while compressive strength showed higher significant values, with ionomers modified with 10% concentration of nanotubes resulting in better compressive strength values. The incorporation of nanotubes at concentrations of 5% and 10% effectively inhibited the presence of S. mutans, particularly when the dose–response relationship was taken into account, with the advantage of maintaining and improving their mechanical properties. MDPI 2022-08-23 /pmc/articles/PMC9457761/ /pubmed/36079929 http://dx.doi.org/10.3390/nano12172891 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Salmerón-Valdés, Elias Nahum
Cruz-Mondragón, Ana Cecilia
Toral-Rizo, Víctor Hugo
Jiménez-Rojas, Leticia Verónica
Correa-Prado, Rodrigo
Lara-Carrillo, Edith
Morales-Valenzuela, Adriana Alejandra
Scougall-Vilchis, Rogelio José
López-Flores, Alejandra Itzel
Hoz-Rodriguez, Lia
Velásquez-Enríquez, Ulises
Mechanical Properties and Antibacterial Effect on Mono-Strain of Streptococcus mutans of Orthodontic Cements Reinforced with Chlorhexidine-Modified Nanotubes
title Mechanical Properties and Antibacterial Effect on Mono-Strain of Streptococcus mutans of Orthodontic Cements Reinforced with Chlorhexidine-Modified Nanotubes
title_full Mechanical Properties and Antibacterial Effect on Mono-Strain of Streptococcus mutans of Orthodontic Cements Reinforced with Chlorhexidine-Modified Nanotubes
title_fullStr Mechanical Properties and Antibacterial Effect on Mono-Strain of Streptococcus mutans of Orthodontic Cements Reinforced with Chlorhexidine-Modified Nanotubes
title_full_unstemmed Mechanical Properties and Antibacterial Effect on Mono-Strain of Streptococcus mutans of Orthodontic Cements Reinforced with Chlorhexidine-Modified Nanotubes
title_short Mechanical Properties and Antibacterial Effect on Mono-Strain of Streptococcus mutans of Orthodontic Cements Reinforced with Chlorhexidine-Modified Nanotubes
title_sort mechanical properties and antibacterial effect on mono-strain of streptococcus mutans of orthodontic cements reinforced with chlorhexidine-modified nanotubes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457761/
https://www.ncbi.nlm.nih.gov/pubmed/36079929
http://dx.doi.org/10.3390/nano12172891
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