Development and Validation of a Sensitive and Specific LC-MS/MS Method for IWR-1-Endo, a Wnt Signaling Inhibitor: Application to a Cerebral Microdialysis Study

IWR-1-endo, a small molecule that potently inhibits the Wnt/β-catenin signaling pathway by stabilizing the AXIN2 destruction complex, can inhibit drug efflux at the blood–brain barrier. To conduct murine cerebral microdialysis research, validated, sensitive, and reliable liquid chromatography–tandem...

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Detalles Bibliográficos
Autores principales: Nair, Sreenath, Davis, Abigail, Campagne, Olivia, Schuetz, John D., Stewart, Clinton F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457781/
https://www.ncbi.nlm.nih.gov/pubmed/36080214
http://dx.doi.org/10.3390/molecules27175448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457781/
https://www.ncbi.nlm.nih.gov/pubmed/36080214
http://dx.doi.org/10.3390/molecules27175448

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