Synthesis and Kinase Inhibitory Potencies of Pyrazolo[3,4-g]isoquinolines

A new series of pyrazolo[3,4-g]isoquinoline derivatives, diversely substituted at the 4- or 8-position, were synthesized. The results of the kinase inhibitory potency study demonstrated that the introduction of a bromine atom at the 8-position was detrimental to Haspin inhibition, while the introduc...

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Detalles Bibliográficos
Autores principales: Defois, Mathilde, Rémondin, Chloé, Josselin, Béatrice, Nauton, Lionel, Théry, Vincent, Anizon, Fabrice, Ruchaud, Sandrine, Giraud, Francis, Moreau, Pascale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457941/
https://www.ncbi.nlm.nih.gov/pubmed/36080340
http://dx.doi.org/10.3390/molecules27175578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457941/
https://www.ncbi.nlm.nih.gov/pubmed/36080340
http://dx.doi.org/10.3390/molecules27175578

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