Scalable (Enantioselective) Syntheses of Novel 3-Methylated Analogs of Pazinaclone, (S)-PD172938 and Related Biologically Relevant Isoindolinones

Herein, we report the application of an efficient and practical K(2)CO(3) promoted cascade reaction of 2-acetylbenzonitrile in the synthesis of novel 3-methylated analogs of Pazinaclone and PD172938, belonging to isoindolinones heterocyclic class bearing a tetrasubstituted stereocenter. Organocataly...

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Detalles Bibliográficos
Autores principales: Di Mola, Antonia, Nicastro, Giorgia, Serusi, Lorenzo, Filosa, Rosanna, Waser, Mario, Massa, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458024/
https://www.ncbi.nlm.nih.gov/pubmed/36080411
http://dx.doi.org/10.3390/molecules27175647

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458024/
https://www.ncbi.nlm.nih.gov/pubmed/36080411
http://dx.doi.org/10.3390/molecules27175647

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