Synthesis of N-Substituted Iminosugar C-Glycosides and Evaluation as Promising α-Glucosidase Inhibitors

A series of N-substituted iminosugar C-glycosides were synthesized and tested for α-glucosidase inhibition. The results suggested that 6e is a promising and potent α-glucosidase inhibitor. Enzymatic kinetic assays indicated that compound 6e may be classified as an uncompetitive inhibitor. The study...

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Detalles Bibliográficos
Autores principales: Wang, Haibo, Tang, Senling, Zhang, Guoqing, Pan, Yang, Jiao, Wei, Shao, Huawu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458058/
https://www.ncbi.nlm.nih.gov/pubmed/36080282
http://dx.doi.org/10.3390/molecules27175517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458058/
https://www.ncbi.nlm.nih.gov/pubmed/36080282
http://dx.doi.org/10.3390/molecules27175517

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