Synthesis of N-Substituted Iminosugar C-Glycosides and Evaluation as Promising α-Glucosidase Inhibitors

A series of N-substituted iminosugar C-glycosides were synthesized and tested for α-glucosidase inhibition. The results suggested that 6e is a promising and potent α-glucosidase inhibitor. Enzymatic kinetic assays indicated that compound 6e may be classified as an uncompetitive inhibitor. The study...

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Detalles Bibliográficos
Autores principales: Wang, Haibo, Tang, Senling, Zhang, Guoqing, Pan, Yang, Jiao, Wei, Shao, Huawu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458058/
https://www.ncbi.nlm.nih.gov/pubmed/36080282
http://dx.doi.org/10.3390/molecules27175517
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author Wang, Haibo
Tang, Senling
Zhang, Guoqing
Pan, Yang
Jiao, Wei
Shao, Huawu
author_facet Wang, Haibo
Tang, Senling
Zhang, Guoqing
Pan, Yang
Jiao, Wei
Shao, Huawu
author_sort Wang, Haibo
collection PubMed
description A series of N-substituted iminosugar C-glycosides were synthesized and tested for α-glucosidase inhibition. The results suggested that 6e is a promising and potent α-glucosidase inhibitor. Enzymatic kinetic assays indicated that compound 6e may be classified as an uncompetitive inhibitor. The study of structure-activity relationships of those iminosugars provided a starting point for the discovery of new α-glucosidase inhibitors.
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spelling pubmed-94580582022-09-09 Synthesis of N-Substituted Iminosugar C-Glycosides and Evaluation as Promising α-Glucosidase Inhibitors Wang, Haibo Tang, Senling Zhang, Guoqing Pan, Yang Jiao, Wei Shao, Huawu Molecules Article A series of N-substituted iminosugar C-glycosides were synthesized and tested for α-glucosidase inhibition. The results suggested that 6e is a promising and potent α-glucosidase inhibitor. Enzymatic kinetic assays indicated that compound 6e may be classified as an uncompetitive inhibitor. The study of structure-activity relationships of those iminosugars provided a starting point for the discovery of new α-glucosidase inhibitors. MDPI 2022-08-27 /pmc/articles/PMC9458058/ /pubmed/36080282 http://dx.doi.org/10.3390/molecules27175517 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Haibo
Tang, Senling
Zhang, Guoqing
Pan, Yang
Jiao, Wei
Shao, Huawu
Synthesis of N-Substituted Iminosugar C-Glycosides and Evaluation as Promising α-Glucosidase Inhibitors
title Synthesis of N-Substituted Iminosugar C-Glycosides and Evaluation as Promising α-Glucosidase Inhibitors
title_full Synthesis of N-Substituted Iminosugar C-Glycosides and Evaluation as Promising α-Glucosidase Inhibitors
title_fullStr Synthesis of N-Substituted Iminosugar C-Glycosides and Evaluation as Promising α-Glucosidase Inhibitors
title_full_unstemmed Synthesis of N-Substituted Iminosugar C-Glycosides and Evaluation as Promising α-Glucosidase Inhibitors
title_short Synthesis of N-Substituted Iminosugar C-Glycosides and Evaluation as Promising α-Glucosidase Inhibitors
title_sort synthesis of n-substituted iminosugar c-glycosides and evaluation as promising α-glucosidase inhibitors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458058/
https://www.ncbi.nlm.nih.gov/pubmed/36080282
http://dx.doi.org/10.3390/molecules27175517
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