Discovery of Quinacrine as a Potent Topo II and Hsp90 Dual-Target Inhibitor, Repurposing for Cancer Therapy

Topo II and Hsp90 are promising targets. In this study, we first verified the structural similarities between Topo IIα ATPase and Hsp90α N−ATPase. Subsequently, 720 compounds from the Food and Drug Administration (FDA) drug library and kinase library were screened using the malachite green phosphate...

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Detalles Bibliográficos
Autores principales: Pan, Xin, Mao, Teng-yu, Mai, Yan-wen, Liang, Cheng-cheng, Huang, Wei-hao, Rao, Yong, Huang, Zhi-shu, Huang, Shi-liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458065/
https://www.ncbi.nlm.nih.gov/pubmed/36080326
http://dx.doi.org/10.3390/molecules27175561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458065/
https://www.ncbi.nlm.nih.gov/pubmed/36080326
http://dx.doi.org/10.3390/molecules27175561

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