Chiral Discrimination of Mexiletine Enantiomers by Capillary Electrophoresis Using Cyclodextrins as Chiral Selectors and Experimental Design Method Optimization

Mexiletine (MXL) is a class IB antiarrhythmic agent, acting as a non-selective voltage-gated sodium channel blocker, used in therapy as a racemic mixture R,S-MXL hydrochloride. The aim of the current study was the development of a new, fast, and efficient method for the chiral separation of MXL enan...

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Detalles Bibliográficos
Autores principales: Cârcu-Dobrin, Melania, Hancu, Gabriel, Papp, Lajos Attila, Fülöp, Ibolya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458186/
https://www.ncbi.nlm.nih.gov/pubmed/36080370
http://dx.doi.org/10.3390/molecules27175603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458186/
https://www.ncbi.nlm.nih.gov/pubmed/36080370
http://dx.doi.org/10.3390/molecules27175603

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