A photochemically covalent lock stabilizes aptamer conformation and strengthens its performance for biomedicine

Aptamers’ vast conformation ensemble consisting of interconverting substates severely impairs their performance and applications in biomedicine. Therefore, developing new chemistries stabilizing aptamer conformation and exploring the conformation–performance relationship are highly desired. Herein,...

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Detalles Bibliográficos
Autores principales: Zhou, Fang, Wang, Peng, Chen, Jianghuai, Zhu, Zhijia, Li, Youshan, Wang, Sujuan, Wu, Shanchao, Sima, Yingyu, Fu, Ting, Tan, Weihong, Zhao, Zilong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458419/
https://www.ncbi.nlm.nih.gov/pubmed/35993818
http://dx.doi.org/10.1093/nar/gkac703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458419/
https://www.ncbi.nlm.nih.gov/pubmed/35993818
http://dx.doi.org/10.1093/nar/gkac703

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