A deafness-associated mitochondrial DNA mutation caused pleiotropic effects on DNA replication and tRNA metabolism

In this report, we investigated the molecular mechanism underlying a deafness-associated m.5783C > T mutation that affects the canonical C50-G63 base-pairing of TΨC stem of tRNA(Cys) and immediately adjacent to 5′ end of light-strand origin of mitochondrial DNA (mtDNA) replication (OriL). Two dim...

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Detalles Bibliográficos
Autores principales: Meng, Feilong, Jia, Zidong, Zheng, Jing, Ji, Yanchun, Wang, Jing, Xiao, Yun, Fu, Yong, Wang, Meng, Ling, Feng, Guan, Min-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458427/
https://www.ncbi.nlm.nih.gov/pubmed/36039763
http://dx.doi.org/10.1093/nar/gkac720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458427/
https://www.ncbi.nlm.nih.gov/pubmed/36039763
http://dx.doi.org/10.1093/nar/gkac720

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