Cargando…

A deafness-associated mitochondrial DNA mutation caused pleiotropic effects on DNA replication and tRNA metabolism

In this report, we investigated the molecular mechanism underlying a deafness-associated m.5783C > T mutation that affects the canonical C50-G63 base-pairing of TΨC stem of tRNA(Cys) and immediately adjacent to 5′ end of light-strand origin of mitochondrial DNA (mtDNA) replication (OriL). Two dim...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meng, Feilong, Jia, Zidong, Zheng, Jing, Ji, Yanchun, Wang, Jing, Xiao, Yun, Fu, Yong, Wang, Meng, Ling, Feng, Guan, Min-Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458427/ https://www.ncbi.nlm.nih.gov/pubmed/36039763 http://dx.doi.org/10.1093/nar/gkac720

Ejemplares similares

A deafness-associated tRNA mutation caused pleiotropic effects on the m(1)G37 modification, processing, stability and aminoacylation of tRNA(Ile) and mitochondrial translation
por: Meng, Feilong, et al.
Publicado: (2021)

Asymmetrical effects of deafness-associated mitochondrial DNA 7516delA mutation on the processing of RNAs in the H-strand and L-strand polycistronic transcripts
por: Xiao, Yun, et al.
Publicado: (2020)

Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNA(Asn), tRNA(Gln), tRNA(Glu) and tRNA(Pro)
por: Jia, Zidong, et al.
Publicado: (2022)

A coronary artery disease-associated tRNA(Thr) mutation altered mitochondrial function, apoptosis and angiogenesis
por: Jia, Zidong, et al.
Publicado: (2019)

Hypertension-associated mitochondrial DNA 4401A>G mutation caused the aberrant processing of tRNA(Met), all 8 tRNAs and ND6 mRNA in the light-strand transcript
por: Zhao, Xiaoxu, et al.
Publicado: (2019)

Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism
por: Chen, Danni, et al.
Publicado: (2019)

Mitochondrial RNA granules are critically dependent on mtDNA replication factors Twinkle and mtSSB
por: Hensen, Fenna, et al.
Publicado: (2019)

Aberrant RNA processing contributes to the pathogenesis of mitochondrial diseases in trans-mitochondrial mouse model carrying mitochondrial tRNA(Leu(UUR)) with a pathogenic A2748G mutation
por: Tani, Haruna, et al.
Publicado: (2022)

FARS2 deficiency in Drosophila reveals the developmental delay and seizure manifested by aberrant mitochondrial tRNA metabolism
por: Fan, Wenlu, et al.
Publicado: (2021)

Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function
por: Zhang, Qinghai, et al.
Publicado: (2018)

A deafness-associated tRNA(Asp) mutation alters the m(1)G37 modification, aminoacylation and stability of tRNA(Asp) and mitochondrial function
por: Wang, Meng, et al.
Publicado: (2016)

A deafness-associated tRNA(His) mutation alters the mitochondrial function, ROS production and membrane potential
por: Gong, Shasha, et al.
Publicado: (2014)

Domain collapse and active site ablation generate a widespread animal mitochondrial seryl-tRNA synthetase
por: de Potter, Bastiaan, et al.
Publicado: (2023)

Fetal antisense oligonucleotide therapy for congenital deafness and vestibular dysfunction
por: Wang, Lingyan, et al.
Publicado: (2020)

A new bacterial tRNA enhances antibiotic production in Streptomyces by circumventing inefficient wobble base-pairing
por: Chen, Ximing, et al.
Publicado: (2022)

Kti12, a PSTK-like tRNA dependent ATPase essential for tRNA modification by Elongator
por: Krutyhołowa, Rościsław, et al.
Publicado: (2019)

Cooperative methylation of human tRNA(3)(Lys) at positions A58 and U54 drives the early and late steps of HIV-1 replication
por: Fukuda, Hiroyuki, et al.
Publicado: (2021)

Position 34 of tRNA is a discriminative element for m(5)C38 modification by human DNMT2
por: Huang, Zhi-Xuan, et al.
Publicado: (2021)

A homozygous mutation in the human selenocysteine tRNA gene impairs UGA recoding activity and selenoproteome regulation by selenium
por: Vindry, Caroline, et al.
Publicado: (2023)

Regulation of La/SSB-dependent viral gene expression by pre-tRNA 3′ trailer-derived tRNA fragments
por: Cho, Hee, et al.
Publicado: (2019)

Let's make it clear: systematic exploration of mitochondrial DNA– and RNA–protein complexes by complexome profiling
por: Potter, Alisa, et al.
Publicado: (2023)

Dynamics of intracellular stress-induced tRNA trafficking
por: Dhakal, Rabin, et al.
Publicado: (2019)

Twice exploration of tRNA +1 frameshifting in an elongation cycle of protein synthesis
por: Gamper, Howard, et al.
Publicado: (2021)

Single molecule analysis of effects of non-canonical guide RNAs and specificity-enhancing mutations on Cas9-induced DNA unwinding
por: Okafor, Ikenna C, et al.
Publicado: (2019)

Distributive enzyme binding controlled by local RNA context results in 3′ to 5′ directional processing of dicistronic tRNA precursors by Escherichia coli ribonuclease P
por: Zhao, Jing, et al.
Publicado: (2019)

Charcot–Marie–Tooth mutation in glycyl-tRNA synthetase stalls ribosomes in a pre-accommodation state and activates integrated stress response
por: Mendonsa, Samantha, et al.
Publicado: (2021)

Sustenance of Escherichia coli on a single tRNA(Met)
por: Govindan, Ashwin, et al.
Publicado: (2018)

Hierarchical groove discrimination by Class I and II aminoacyl-tRNA synthetases reveals a palimpsest of the operational RNA code in the tRNA acceptor-stem bases
por: Carter, Charles W, et al.
Publicado: (2018)

Impact of intron removal from tRNA genes on Saccharomyces cerevisiae
por: Hayashi, Sachiko, et al.
Publicado: (2019)

GNAT toxins evolve toward narrow tRNA target specificities
por: Bikmetov, Dmitry, et al.
Publicado: (2022)

THUMPD3–TRMT112 is a m(2)G methyltransferase working on a broad range of tRNA substrates
por: Yang, Wen-Qing, et al.
Publicado: (2021)

Three tRNA nuclear exporters in S. cerevisiae: parallel pathways, preferences, and precision
por: Chatterjee, Kunal, et al.
Publicado: (2022)

Restoration of mitochondrial function through activation of hypomodified tRNAs with pathogenic mutations associated with mitochondrial diseases
por: Tomoda, Ena, et al.
Publicado: (2023)

Structural insights into target DNA recognition and cleavage by the CRISPR-Cas12c1 system
por: Zhang, Bo, et al.
Publicado: (2022)

Seryl-tRNA synthetase promotes translational readthrough by mRNA binding and involvement of the selenocysteine incorporation machinery
por: Liu, Ze, et al.
Publicado: (2023)

N (6)-methyladenosine modification and METTL3 modulate enterovirus 71 replication
por: Hao, Haojie, et al.
Publicado: (2019)

tRNA 3′ shortening by LCCR4 as a response to stress in Trypanosoma brucei
por: Cristodero, Marina, et al.
Publicado: (2021)

Pseudouridine-mediated translation control of mRNA by methionine aminoacyl tRNA synthetase
por: Levi, Ofri, et al.
Publicado: (2020)

Dicer dependent tRNA derived small RNAs promote nascent RNA silencing
por: Di Fazio, Arianna, et al.
Publicado: (2022)

Eukaryotic tRNA sequences present conserved and amino acid-specific structural signatures
por: Westhof, Eric, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_um8062d08u2941ebn1lp3cedgn