2′-O-Methylation of the second transcribed nucleotide within the mRNA 5′ cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion

In mammals, m(7)G-adjacent nucleotides undergo extensive modifications. Ribose of the first or first and second transcribed nucleotides can be subjected to 2′-O-methylation to form cap1 or cap2, respectively. When the first transcribed nucleotide is 2′-O-methylated adenosine, it can be additionally...

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Detalles Bibliográficos
Autores principales: Drazkowska, Karolina, Tomecki, Rafal, Warminski, Marcin, Baran, Natalia, Cysewski, Dominik, Depaix, Anaïs, Kasprzyk, Renata, Kowalska, Joanna, Jemielity, Jacek, Sikorski, Pawel J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458431/
https://www.ncbi.nlm.nih.gov/pubmed/36018811
http://dx.doi.org/10.1093/nar/gkac722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458431/
https://www.ncbi.nlm.nih.gov/pubmed/36018811
http://dx.doi.org/10.1093/nar/gkac722

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