Domain specific mutations in dyskerin disrupt 3′ end processing of scaRNA13

Mutations in DKC1 (encoding dyskerin) cause telomere diseases including dyskeratosis congenita (DC) by decreasing steady-state levels of TERC, the non-coding RNA component of telomerase. How DKC1 mutations variably impact numerous other snoRNAs remains unclear, which is a barrier to understanding di...

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Detalles Bibliográficos
Autores principales: Nagpal, Neha, Tai, Albert K, Nandakumar, Jayakrishnan, Agarwal, Suneet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458449/
https://www.ncbi.nlm.nih.gov/pubmed/36018809
http://dx.doi.org/10.1093/nar/gkac706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458449/
https://www.ncbi.nlm.nih.gov/pubmed/36018809
http://dx.doi.org/10.1093/nar/gkac706

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