Cargando…

Domain specific mutations in dyskerin disrupt 3′ end processing of scaRNA13

Mutations in DKC1 (encoding dyskerin) cause telomere diseases including dyskeratosis congenita (DC) by decreasing steady-state levels of TERC, the non-coding RNA component of telomerase. How DKC1 mutations variably impact numerous other snoRNAs remains unclear, which is a barrier to understanding di...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nagpal, Neha, Tai, Albert K, Nandakumar, Jayakrishnan, Agarwal, Suneet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458449/ https://www.ncbi.nlm.nih.gov/pubmed/36018809 http://dx.doi.org/10.1093/nar/gkac706

Ejemplares similares

N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation
por: MacNeil, Deanna E, et al.
Publicado: (2019)

LOTUS domain is a novel class of G-rich and G-quadruplex RNA binding domain
por: Ding, Deqiang, et al.
Publicado: (2020)

Structural disruption of exonic stem–loops immediately upstream of the intron regulates mammalian splicing
por: Saha, Kaushik, et al.
Publicado: (2020)

Structural characterization of the ANTAR antiterminator domain bound to RNA
por: Walshe, James L, et al.
Publicado: (2022)

High-resolution RNA 3′-ends mapping of bacterial Rho-dependent transcripts
por: Dar, Daniel, et al.
Publicado: (2018)

Elements at the 5′ end of Xist harbor SPEN-independent transcriptional antiterminator activity
por: Trotman, Jackson B, et al.
Publicado: (2020)

Nearest neighbor rules for RNA helix folding thermodynamics: improved end effects
por: Zuber, Jeffrey, et al.
Publicado: (2022)

Expanding RNA binding specificity and affinity of engineered PUF domains
por: Zhao, Yang-Yang, et al.
Publicado: (2018)

Differences in the path to exit the ribosome across the three domains of life
por: Dao Duc, Khanh, et al.
Publicado: (2019)

Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns
por: Olthof, Anouk M, et al.
Publicado: (2021)

Mapping domains of ARS2 critical for its RNA decay capacity
por: Melko, Mireille, et al.
Publicado: (2020)

Bias-minimized quantification of microRNA reveals widespread alternative processing and 3′ end modification
por: Kim, Haedong, et al.
Publicado: (2019)

Role of the 5′ end phosphorylation state for small RNA stability and target RNA regulation in bacteria
por: Schilder, Alexandra, et al.
Publicado: (2023)

Altered rRNA processing disrupts nuclear RNA homeostasis via competition for the poly(A)-binding protein Nab2
por: Aguilar, Lisbeth-Carolina, et al.
Publicado: (2020)

Sequential disruption of SPLASH-identified vRNA–vRNA interactions challenges their role in influenza A virus genome packaging
por: Jakob, Celia, et al.
Publicado: (2023)

Functional analysis of Cwc24 ZF-domain in 5′ splice site selection
por: Wu, Nan-Ying, et al.
Publicado: (2019)

SWI/SNF interacts with cleavage and polyadenylation factors and facilitates pre-mRNA 3′ end processing
por: Yu, Simei, et al.
Publicado: (2018)

Determinants of RNA recognition by the FinO domain of the Escherichia coli ProQ protein
por: Stein, Ewa M, et al.
Publicado: (2020)

Functional expansion of a TCA cycle operon mRNA by a 3′ end-derived small RNA
por: Miyakoshi, Masatoshi, et al.
Publicado: (2019)

Interplay of endonucleolytic and exonucleolytic processing in the 3′-end formation of a mitochondrial nad2 RNA precursor in Arabidopsis
por: Wang, Chuande, et al.
Publicado: (2023)

Distinct roles for the IIId2 sub-domain in pestivirus and picornavirus internal ribosome entry sites
por: Willcocks, Margaret M., et al.
Publicado: (2017)

Functional specialization of monocot DCL3 and DCL5 proteins through the evolution of the PAZ domain
por: Chen, Shirui, et al.
Publicado: (2022)

Tissue-selective restriction of RNA editing of Ca(V)1.3 by splicing factor SRSF9
por: Huang, Hua, et al.
Publicado: (2018)

N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing
por: Bartosovic, Marek, et al.
Publicado: (2017)

Structural basis of tRNA(Pro) acceptor stem recognition by a bacterial trans-editing domain
por: Ma, Xiao, et al.
Publicado: (2023)

The conserved AU dinucleotide at the 5′ end of nascent U1 snRNA is optimized for the interaction with nuclear cap-binding-complex
por: Yeh, Chung-Shu, et al.
Publicado: (2017)

Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein
por: Li, Jiexin, et al.
Publicado: (2020)

Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2
por: Bou-Nader, Charles, et al.
Publicado: (2019)

Domain function and predicted structure of three heterodimeric endonuclease subunits of RNA editing catalytic complexes in Trypanosoma brucei
por: Carnes, Jason, et al.
Publicado: (2022)

Domain collapse and active site ablation generate a widespread animal mitochondrial seryl-tRNA synthetase
por: de Potter, Bastiaan, et al.
Publicado: (2023)

Human histone pre-mRNA assembles histone or canonical mRNA-processing complexes by overlapping 3′-end sequence elements
por: Ielasi, Francesco S, et al.
Publicado: (2022)

An improved method for circular RNA purification using RNase R that efficiently removes linear RNAs containing G-quadruplexes or structured 3′ ends
por: Xiao, Mei-Sheng, et al.
Publicado: (2019)

Inhibition of cytoplasmic cap methylation identifies 5′ TOP mRNAs as recapping targets and reveals recapping sites downstream of native 5′ ends
por: del Valle Morales, Daniel, et al.
Publicado: (2020)

TGS1 impacts snRNA 3′-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration
por: Chen, Lu, et al.
Publicado: (2022)

Staufen1 and UPF1 exert opposite actions on the replacement of the nuclear cap-binding complex by eIF4E at the 5′ end of mRNAs
por: Jeong, Kwon, et al.
Publicado: (2019)

Dynamics of the DEAD-box ATPase Prp5 RecA-like domains provide a conformational switch during spliceosome assembly
por: Beier, David H, et al.
Publicado: (2019)

Saturation mutagenesis charts the functional landscape of Salmonella ProQ and reveals a gene regulatory function of its C-terminal domain
por: Rizvanovic, Alisa, et al.
Publicado: (2021)

SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction
por: Lavigne, Marc, et al.
Publicado: (2021)

Allosteric activation of CRISPR-Cas12a requires the concerted movement of the bridge helix and helix 1 of the RuvC II domain
por: Wörle, Elisabeth, et al.
Publicado: (2022)

A fish herpesvirus highlights functional diversities among Zα domains related to phase separation induction and A-to-Z conversion
por: Diallo, Mamadou Amadou, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_bkbj9d4jhqgm3ptl3ddn0n3e24