Biochemical and structural characterization of hepatitis A virus 2C reveals an unusual ribonuclease activity on single-stranded RNA

The HAV nonstructural protein 2C is essential for virus replication; however, its precise function remains elusive. Although HAV 2C shares 24–27% sequence identity with other 2Cs, key motifs are conserved. Here, we demonstrate that HAV 2C is an ATPase but lacking helicase activity. We identified an...

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Detalles Bibliográficos
Autores principales: Chen, Pu, Wojdyla, Justyna Aleksandra, Colasanti, Ombretta, Li, Zhijian, Qin, Bo, Wang, Meitian, Lohmann, Volker, Cui, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458454/
https://www.ncbi.nlm.nih.gov/pubmed/35947700
http://dx.doi.org/10.1093/nar/gkac671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458454/
https://www.ncbi.nlm.nih.gov/pubmed/35947700
http://dx.doi.org/10.1093/nar/gkac671

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