ATRX histone binding and helicase activities have distinct roles in neuronal differentiation

ATRX is a chromatin remodeler, which is mutated in ATRX syndrome, a neurodevelopmental disorder. ATRX mutations that alter histone binding or chromatin remodeling activities cluster in the PHD finger or the helicase domain respectively. Using engineered mouse embryonic stem cells that exclusively ex...

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Detalles Bibliográficos
Autores principales: Bieluszewska, Anna, Wulfridge, Phillip, Doherty, John, Ren, Wenqing, Sarma, Kavitha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458459/
https://www.ncbi.nlm.nih.gov/pubmed/35998910
http://dx.doi.org/10.1093/nar/gkac683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458459/
https://www.ncbi.nlm.nih.gov/pubmed/35998910
http://dx.doi.org/10.1093/nar/gkac683

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