Disease-associated inosine misincorporation into RNA hinders translation

Failure to prevent accumulation of the non-canonical nucleotide inosine triphosphate (ITP) by inosine triphosphate pyrophosphatase (ITPase) during nucleotide synthesis results in misincorporation of inosine into RNA and can cause severe and fatal developmental anomalies in humans. While the biochemi...

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Detalles Bibliográficos
Autores principales: Schroader, Jacob H, Jones, Lindsey A, Meng, Ryan, Shorrock, Hannah K, Richardson, Jared I, Shaughnessy, Sharon M, Lin, Qishan, Begley, Thomas J, Berglund, J Andrew, Fuchs, Gabriele, Handley, Mark T, Reddy, Kaalak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458462/
https://www.ncbi.nlm.nih.gov/pubmed/35979951
http://dx.doi.org/10.1093/nar/gkac709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458462/
https://www.ncbi.nlm.nih.gov/pubmed/35979951
http://dx.doi.org/10.1093/nar/gkac709

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