Cargando…

GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection

Cellular necrosis during Mycobacterium tuberculosis (Mtb) infection promotes both immunopathology and bacterial dissemination. Glutathione peroxidase-4 (Gpx4) is an enzyme that plays a critical role in preventing iron-dependent lipid peroxidation–mediated cell death (ferroptosis), a process previous...

Descripción completa

Detalles Bibliográficos
Autores principales:	Amaral, Eduardo P., Foreman, Taylor W., Namasivayam, Sivaranjani, Hilligan, Kerry L., Kauffman, Keith D., Barbosa Bomfim, Caio Cesar, Costa, Diego L., Barreto-Duarte, Beatriz, Gurgel-Rocha, Clarissa, Santana, Monique Freire, Cordeiro-Santos, Marcelo, Du Bruyn, Elsa, Riou, Catherine, Aberman, Kate, Wilkinson, Robert John, Barber, Daniel L., Mayer-Barber, Katrin D., Andrade, Bruno B., Sher, Alan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458471/ https://www.ncbi.nlm.nih.gov/pubmed/36069923 http://dx.doi.org/10.1084/jem.20220504

Ejemplares similares

BCG mediated protection of the lung against experimental SARS-CoV-2 infection
por: Hilligan, Kerry L., et al.
Publicado: (2023)

Helminth exposure protects against murine SARS-CoV-2 infection through macrophage dependent T cell activation
por: Hilligan, Kerry L., et al.
Publicado: (2022)

A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis
por: Amaral, Eduardo P., et al.
Publicado: (2019)

Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge
por: Hilligan, Kerry L., et al.
Publicado: (2021)

Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge
por: Hilligan, Kerry L., et al.
Publicado: (2021)

Correlation between Disease Severity and the Intestinal Microbiome in Mycobacterium tuberculosis-Infected Rhesus Macaques
por: Namasivayam, Sivaranjani, et al.
Publicado: (2019)

Blood and Site of Disease Inflammatory Profiles Differ in Patients With Pericardial Tuberculosis and Human Immunodeficiency Virus Type 1
por: Mutavhatsindi, Hygon, et al.
Publicado: (2023)

Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis
por: Du Bruyn, Elsa, et al.
Publicado: (2020)

Disease extent and anti‐tubercular treatment response correlates with Mycobacterium tuberculosis‐specific CD4 T‐cell phenotype regardless of HIV‐1 status
por: Riou, Catherine, et al.
Publicado: (2020)

Co-infection of mice with SARS-CoV-2 and Mycobacterium tuberculosis limits early viral replication but does not affect mycobacterial loads
por: Baker, Paul J., et al.
Publicado: (2023)

Comparison of the frequency and phenotypic profile of Mycobacterium tuberculosis-specific CD4 T cells between the site of disease and blood in pericardial tuberculosis
por: Du Bruyn, Elsa, et al.
Publicado: (2022)

Corrigendum: Comparison of the frequency and phenotypic profile of Mycobacterium tuberculosis-specific CD4 T cells between the site of disease and blood in pericardial tuberculosis
por: Du Bruyn, Elsa, et al.
Publicado: (2023)

Enhancement of CD4(+) T Cell Function as a Strategy for Improving Antibiotic Therapy Efficacy in Tuberculosis: Does It Work?
por: Costa, Diego L., et al.
Publicado: (2021)

The Microbiome and Tuberculosis: Early Evidence for Cross Talk
por: Namasivayam, Sivaranjani, et al.
Publicado: (2018)

Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates
por: Sakai, Shunsuke, et al.
Publicado: (2021)

The impact of GPX1 on the association of groundwater selenium and depression: a project FRONTIER study
por: Johnson, Leigh A, et al.
Publicado: (2013)

Mycobacterium tuberculosis Induces Irg1 in Murine Macrophages by a Pathway Involving Both TLR-2 and STING/IFNAR Signaling and Requiring Bacterial Phagocytosis
por: Bomfim, Caio C. B., et al.
Publicado: (2022)

Phenotypic Profile of Mycobacterium tuberculosis-Specific CD4 T-Cell Responses in People With Advanced Human Immunodeficiency Virus Who Develop Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome
por: Moseki, Raymond M, et al.
Publicado: (2022)

Heme oxygenase-1 inhibition promotes IFNγ and NOS2 mediated control of Mycobacterium tuberculosis infection
por: Costa, Diego L, et al.
Publicado: (2020)

Translational Regulation of GPx-1 and GPx-4 by the mTOR Pathway
por: Reinke, Emily N., et al.
Publicado: (2014)

Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles
por: Hilligan, Kerry L., et al.
Publicado: (2020)

Persistent Oxidative Stress and Inflammasome Activation in CD14(high)CD16(−) Monocytes From COVID-19 Patients
por: Lage, Silvia Lucena, et al.
Publicado: (2022)

GPX4 and GPX7 Over-Expression in Human Hepatocellular Carcinoma Tissues
por: Guerriero, E., et al.
Publicado: (2015)

The Dysbiosis Triggered by First-Line Tuberculosis Antibiotics Fails to Reduce Their Bioavailability
por: Namasivayam, Sivaranjani, et al.
Publicado: (2023)

Evaluation of endogenous and therapeutic 25-hydroxycholesterols in murine models of pulmonary SARS-CoV-2 infection
por: Fessler, Michael B., et al.
Publicado: (2022)

Type I IFN Induction via Poly-ICLC Protects Mice against Cryptococcosis
por: Sionov, Edward, et al.
Publicado: (2015)

Type I interferons in tuberculosis: Foe and occasionally friend
por: Moreira-Teixeira, Lúcia, et al.
Publicado: (2018)

CD30 co-stimulation drives differentiation of protective T cells during Mycobacterium tuberculosis infection
por: Foreman, Taylor W., et al.
Publicado: (2023)

Exploring the online learning experience of first-year speech–language pathology students in a Johannesburg-based university
por: Barber, Nancy, et al.
Publicado: (2022)

Chosen Antioxidant Enzymes GPx4 and GPx8 in Human Colorectal Carcinoma: Study of the Slovak Population
por: Pavliuk-Karachevtseva, Andriana, et al.
Publicado: (2022)

Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infection
por: Bohrer, Andrea C., et al.
Publicado: (2022)

Activation-Induced TIM-4 Expression Identifies Differential Responsiveness of Intestinal CD103+ CD11b+ Dendritic Cells to a Mucosal Adjuvant
por: Hilligan, Kerry L., et al.
Publicado: (2016)

Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium
por: Chu, Fong-Fong, et al.
Publicado: (2016)

Extracellular Glutathione Peroxidase GPx3 and Its Role in Cancer
por: Chang, Caroline, et al.
Publicado: (2020)

Simultaneous detection of the enzyme activities of GPx1 and GPx4 guide optimization of selenium in cell biological experiments
por: Stolwijk, Jeffrey M., et al.
Publicado: (2020)

Pharmacological Inhibition of Host Heme Oxygenase-1 Suppresses Mycobacterium tuberculosis Infection In Vivo by a Mechanism Dependent on T Lymphocytes
por: Costa, Diego L., et al.
Publicado: (2016)

Comprehensive analysis of epigenetics regulation, prognostic and the correlation with immune infiltrates of GPX7 in adult gliomas
por: Ferreira, Wallax Augusto Silva, et al.
Publicado: (2022)

Epididymis Response Partly Compensates for Spermatozoa Oxidative Defects in snGPx4 and GPx5 Double Mutant Mice
por: Noblanc, Anaïs, et al.
Publicado: (2012)

GPX7 Is Targeted by miR-29b and GPX7 Knockdown Enhances Ferroptosis Induced by Erastin in Glioma
por: Zhou, Yan, et al.
Publicado: (2022)

Glutathione Peroxidase gpx1 to gpx8 Genes Expression in Experimental Brain Tumors Reveals Gender-Dependent Patterns
por: Cueto-Ureña, Cristina, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5k7bdve6h3920hurr613q3i5l1