MAD2L2 promotes replication fork protection and recovery in a shieldin-independent and REV3L-dependent manner

Protection of stalled replication forks is essential to prevent genome instability, a major driving force of tumorigenesis. Several key regulators of DNA double-stranded break (DSB) repair, including 53BP1 and RIF1, have been implicated in fork protection. MAD2L2, also known as REV7, plays an import...

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Detalles Bibliográficos
Autores principales: Paniagua, Inés, Tayeh, Zainab, Falcone, Mattia, Hernández Pérez, Santiago, Cerutti, Aurora, Jacobs, Jacqueline J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458726/
https://www.ncbi.nlm.nih.gov/pubmed/36075897
http://dx.doi.org/10.1038/s41467-022-32861-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458726/
https://www.ncbi.nlm.nih.gov/pubmed/36075897
http://dx.doi.org/10.1038/s41467-022-32861-5

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