Tau isoform-specific enhancement of L-type calcium current and augmentation of afterhyperpolarization in rat hippocampal neurons

Accumulation of tau is observed in dementia, with human tau displaying 6 isoforms grouped by whether they display either 3 or 4 C-terminal repeat domains (3R or 4R) and exhibit no (0N), one (1N) or two (2N) N terminal repeats. Overexpression of 4R0N-tau in rat hippocampal slices enhanced the L-type...

Descripción completa

Detalles Bibliográficos
Autores principales: Stan, Georgiana F., Church, Timothy W., Randall, Ellie, Harvey, Jenna R. M., Brown, Jon T., Wilkinson, Kevin A., Hanley, Jonathan G., Marrion, Neil V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458744/
https://www.ncbi.nlm.nih.gov/pubmed/36075936
http://dx.doi.org/10.1038/s41598-022-18648-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458744/
https://www.ncbi.nlm.nih.gov/pubmed/36075936
http://dx.doi.org/10.1038/s41598-022-18648-0

Ejemplares similares