Mechanistic and pharmacodynamic studies of DuoBody-CD3x5T4 in preclinical tumor models

CD3 bispecific antibodies (bsAbs) show great promise as anticancer therapeutics. Here, we show in-depth mechanistic studies of a CD3 bsAb in solid cancer, using DuoBody-CD3x5T4. Cross-linking T cells with tumor cells expressing the oncofetal antigen 5T4 was required to induce cytotoxicity. Naive and...

Descripción completa

Detalles Bibliográficos
Autores principales: Kemper, Kristel, Gielen, Ellis, Boross, Peter, Houtkamp, Mischa, Plantinga, Theo S, de Poot, Stefanie AH, Burm, Saskia M, Janmaat, Maarten L, Koopman, Louise A, van den Brink, Edward N, Rademaker, Rik, Verzijl, Dennis, Engelberts, Patrick J, Satijn, David, Sasser, A Kate, Breij, Esther CW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458754/
https://www.ncbi.nlm.nih.gov/pubmed/36271507
http://dx.doi.org/10.26508/lsa.202201481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458754/
https://www.ncbi.nlm.nih.gov/pubmed/36271507
http://dx.doi.org/10.26508/lsa.202201481

Ejemplares similares