Evaluating the immunogenicity of heparin and heparin derivatives by measuring their binding to platelet factor 4 using biolayer interferometry

Heparin (HP) is a polysaccharide that is widely used in the clinic as an anticoagulant. A major side effect associated with HP is the heparin-induced thrombocytopenia (HIT), which is initiated by the immune response to complex formed by HP and platelet factor 4 (PF4). Low molecular weight heparins (...

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Detalles Bibliográficos
Autores principales: Chen, Qingqing, Li, Fei, Wang, Haoran, Bu, Changkai, Shi, Feng, Jin, Lan, Zhang, Qunye, Chi, Lianli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458964/
https://www.ncbi.nlm.nih.gov/pubmed/36090049
http://dx.doi.org/10.3389/fmolb.2022.966754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458964/
https://www.ncbi.nlm.nih.gov/pubmed/36090049
http://dx.doi.org/10.3389/fmolb.2022.966754

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