Cargando…

A stepwise strategy integrating metabolomics and pseudotargeted spectrum–effect relationship to elucidate the potential hepatotoxic components in Polygonum multiflorum

Polygonum multiflorum (PM) Thunb., a typical Chinese herbal medicine with different therapeutic effect in raw and processed forms, has been used worldwide for thousands of years. However, hepatotoxicity caused by PM has raised considerable concern in recent decades. The exploration of toxic componen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Yunfei, Yang, Jianbo, Hu, Xiaowen, Gao, Huiyu, Wang, Pengfei, Wang, Xueting, Liu, Yue, Cheng, Xianlong, Wei, Feng, Ma, Shuangcheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459084/ https://www.ncbi.nlm.nih.gov/pubmed/36091795 http://dx.doi.org/10.3389/fphar.2022.935336

Ejemplares similares

Exploratory Quality Control Study for Polygonum multiflorum Thunb. Using Dinuclear Anthraquinones with Potential Hepatotoxicity
por: Gao, Huiyu, et al.
Publicado: (2022)

Systemic elucidation on the potential bioactive compounds and hypoglycemic mechanism of Polygonum multiflorum based on network pharmacology
por: Song, Yunfei, et al.
Publicado: (2020)

Advances in the Study of the Potential Hepatotoxic Components and Mechanism of Polygonum multiflorum
por: Yu, He-Shui, et al.
Publicado: (2020)

Polygonum multiflorum Thunb.: A Review on Chemical Analysis, Processing Mechanism, Quality Evaluation, and Hepatotoxicity
por: Liu, Yue, et al.
Publicado: (2018)

Investigation of the idiosyncratic hepatotoxicity of Polygonum multiflorum Thunb. through metabolomics using GC-MS
por: Lin, Yan, et al.
Publicado: (2021)

Discovery of Hepatotoxic Equivalent Markers and Mechanism of Polygonum multiflorum Thunb. by Metabolomics Coupled with Molecular Docking
por: Zhang, Yinhuan, et al.
Publicado: (2022)

UPLC/MS/MS-Based Metabolomics Study of the Hepatotoxicity and Nephrotoxicity in Rats Induced by Polygonum multiflorum Thunb.
por: Yan, Yan, et al.
Publicado: (2020)

Susceptibility-Related Cytokine Panel for Prediction of Polygonum multiflorum-Induced Hepatotoxicity in Humans
por: Tu, Can, et al.
Publicado: (2021)

Concurrent severe hepatotoxicity and agranulocytosis induced by Polygonum multiflorum: A case report
por: Shao, You-Lin, et al.
Publicado: (2022)

Polygonumnolides A1–B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb
por: Yang, Jianbo, et al.
Publicado: (2017)

Correction to: Polygonumnolides A1–B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb
por: Yang, Jianbo, et al.
Publicado: (2018)

Investigation of Liver Injury of Polygonum multiflorum Thunb. in Rats by Metabolomics and Traditional Approaches
por: Li, Yun-Xia, et al.
Publicado: (2017)

Hair Growth Promotion Activity and Its Mechanism of Polygonum multiflorum
por: Li, Yunfei, et al.
Publicado: (2015)

Germplasm preservation in vitro of Polygonum multiflorum Thunb
por: Huang, He-Ping, et al.
Publicado: (2014)

Changes of Physicochemical Properties and Immunomodulatory Activity of Polysaccharides During Processing of Polygonum multiflorum Thunb
por: Gu, Donglin, et al.
Publicado: (2022)

Screening for biomarkers of liver injury induced by Polygonum multiflorum: a targeted metabolomic study
por: Dong, Qin, et al.
Publicado: (2015)

New phenolic constituents obtained from Polygonum multiflorum
por: Yang, Jian-bo, et al.
Publicado: (2020)

Interpretation the Hepatotoxicity Based on Pharmacokinetics Investigated Through Oral Administrated Different Extraction Parts of Polygonum multiflorum on Rats
por: Zhang, Miao, et al.
Publicado: (2018)

Effects of Different Processed Products of Polygonum multiflorum on the Liver
por: Li, Ruo-Lan, et al.
Publicado: (2020)

A New Strategy for Quality Evaluation and Identification of Representative Chemical Components in Polygonum multiflorum Thunb.
por: Li, Yun-xia, et al.
Publicado: (2017)

The Study on the Pathogenesis of Pediatric Lymphoma Based on the Combination of Pseudotargeted and Targeted Metabolomics
por: Sun, Hongqi, et al.
Publicado: (2021)

Identification and characterization of the structure–activity relationships involved in UGT1A1 inhibition by anthraquinone and dianthrone constituents of Polygonum multiflorum
por: Wang, Qi, et al.
Publicado: (2017)

Biological Effects of Tetrahydroxystilbene Glucoside: An Active Component of a Rhizome Extracted from Polygonum multiflorum
por: Zhang, Lingling, et al.
Publicado: (2018)

A Computational Toxicology Approach to Screen the Hepatotoxic Ingredients in Traditional Chinese Medicines: Polygonum multiflorum Thunb as a Case Study
por: He, Shuaibing, et al.
Publicado: (2019)

Mechanistic Studies on the Use of Polygonum multiflorum for the Treatment of Hair Graying
por: Han, Ming-Nuan, et al.
Publicado: (2015)

Preventive effects of Polygonum multiflorum on glucocorticoid-induced osteoporosis in rats
por: Zhou, Manru, et al.
Publicado: (2017)

Pseudotargeted Metabolomic Fingerprinting and Deep Learning for Identification and Visualization of Common Pathogens
por: Feng, Ying, et al.
Publicado: (2022)

Rapid Discovery of the Potential Toxic Compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-Based Metabolomics and Correlation Analysis
por: Han, Lifeng, et al.
Publicado: (2019)

On-line identification of the chemical constituents of Polygoni Multiflori Radix by UHPLC-Q-ToF MS/MS
por: Wang, Xueting, et al.
Publicado: (2023)

Characterization of Proanthocyanidins in Stems of Polygonum multiflorum Thunb as Strong Starch Hydrolase Inhibitors
por: Wang, Hongyu, et al.
Publicado: (2013)

Pseudotargeted metabolomics revealed the adaptive mechanism of Draba oreades Schrenk at high altitude
por: Lei, Ling, et al.
Publicado: (2022)

Review of clinical studies of Polygonum multiflorum Thunb. and its isolated bioactive compounds
por: Bounda, Guy-Armel, et al.
Publicado: (2015)

Heshouwu (Polygonum multiflorum Thunb.) Extract Attenuates Bone Loss in Diabetic Mice
por: Ham, Ju Ri, et al.
Publicado: (2019)

Diagnosis and Management of Drug-Induced Liver Injury After the Use of Polygonum multiflorum
por: Zahir, Ali, et al.
Publicado: (2022)

Comparative Studies on Multi-Component Pharmacokinetics of Polygonum multiflorum Thunb Extract After Oral Administration in Different Rat Models
por: Ma, Ninghui, et al.
Publicado: (2021)

Metabolomic Study on Idiosyncratic Liver Injury Induced by Different Extracts of Polygonum multiflorum in Rats Integrated with Pattern Recognition and Enriched Pathways Analysis
por: Li, Chun-Yu, et al.
Publicado: (2016)

Single-nucleotide polymorphisms of HLA and Polygonum multiflorum-induced liver injury in the Han Chinese population
por: Yang, Wan-Na, et al.
Publicado: (2020)

Metabolomics Profiling and Diagnosis Biomarkers Searching for Drug-Induced Liver Injury Implicated to Polygonum multiflorum: A Cross-Sectional Cohort Study
por: Huang, Ying, et al.
Publicado: (2020)

Polygonum multiflorum root extract as a potential candidate for treatment of early graying hair
por: Thang, Nguyen Dinh, et al.
Publicado: (2017)

Effects of Hot Water Extracts from Polygonum multiflorum on Ovariectomy Induced Osteopenia in Mice
por: Hwang, Yun-Ho, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_9u4f9rrq195drbqc1fdgab6l58