A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers

To evaluate senescence mechanisms, including senescence-associated secretory phenotype (SASP), in the motor neuron disease model hSOD1-G93A, we quantified the expression of p16 and p21 and senescence-associated β-galactosidase (SA-β-gal) in nervous tissue. As SASP markers, we measured the mRNA level...

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Detalles Bibliográficos
Autores principales: Torres, Pascual, Anerillas, Carlos, Ramírez-Núñez, Omar, Fernàndez, Anna, Encinas, Mario, Povedano, Mònica, Andrés-Benito, Pol, Ferrer, Isidre, Ayala, Victòria, Pamplona, Reinald, Portero-Otín, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459393/
https://www.ncbi.nlm.nih.gov/pubmed/35916061
http://dx.doi.org/10.1242/dmm.049059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459393/
https://www.ncbi.nlm.nih.gov/pubmed/35916061
http://dx.doi.org/10.1242/dmm.049059

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