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AOP key event relationship report: Linking androgen receptor antagonism with nipple retention
In rat developmental and reproductive toxicity studies, nipple/areola retention (NR) in male offspring is a biomarker for reduced androgen signaling during development. This is because nipples normally regress in male rats in response to androgen signaling during critical stages of development. NR i...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459418/ https://www.ncbi.nlm.nih.gov/pubmed/36090961 http://dx.doi.org/10.1016/j.crtox.2022.100085 |