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AOP key event relationship report: Linking androgen receptor antagonism with nipple retention

In rat developmental and reproductive toxicity studies, nipple/areola retention (NR) in male offspring is a biomarker for reduced androgen signaling during development. This is because nipples normally regress in male rats in response to androgen signaling during critical stages of development. NR i...

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Detalles Bibliográficos
Autores principales: Pedersen, Emilie Bak, Christiansen, Sofie, Svingen, Terje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459418/
https://www.ncbi.nlm.nih.gov/pubmed/36090961
http://dx.doi.org/10.1016/j.crtox.2022.100085