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Kratom alkaloid mitragynine: Inhibition of chemotherapy-induced peripheral neuropathy in mice is dependent on sex and active adrenergic and opioid receptors

Mitragynine (MG) is an alkaloid found in Mitragyna speciosa (kratom) that is used as an herbal remedy for pain relief and opioid withdrawal. MG acts at μ-opioid and α-adrenergic receptors in vitro, but the physiological relevance of this activity in the context of neuropathic pain remains unknown. T...

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Detalles Bibliográficos
Autores principales: Farkas, Daniel J., Foss, Jeffery D., Ward, Sara Jane, Rawls, Scott M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459671/
https://www.ncbi.nlm.nih.gov/pubmed/36093282
http://dx.doi.org/10.1016/j.ibneur.2022.08.007