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Characterization of autochthonous lactobacilli from goat dairy products with probiotic potential for metabolic diseases
The present study aimed to design functional fermented goat milk with probiotic potential for metabolic diseases. Thereby, autochthonous lactobacilli from goat dairy products that target improving the inflammatory, lipid, and glycemic profile were characterized. We designed fermented goat milk using...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459688/ https://www.ncbi.nlm.nih.gov/pubmed/36091951 http://dx.doi.org/10.1016/j.heliyon.2022.e10462 |
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author | Marquez, Antonela Andrada, Estefanía Russo, Matias Bolondi, María Lujan Fabersani, Emanuel Medina, Roxana Gauffin-Cano, Paola |
author_facet | Marquez, Antonela Andrada, Estefanía Russo, Matias Bolondi, María Lujan Fabersani, Emanuel Medina, Roxana Gauffin-Cano, Paola |
author_sort | Marquez, Antonela |
collection | PubMed |
description | The present study aimed to design functional fermented goat milk with probiotic potential for metabolic diseases. Thereby, autochthonous lactobacilli from goat dairy products that target improving the inflammatory, lipid, and glycemic profile were characterized. We designed fermented goat milk using Lactobacillus delbrueckii subsp. indicus CRL1447 as starter strain, supplemented with different probiotic consortia formed by Limosilactobacillus fermentum CRL1446, Lactiplantibacillus paraplantarum CRL1449, and CRL1472 strains. These lactobacilli were selected for their positive effects on inhibition of α-glucosidase, bile salts hydrolase activity, cholesterol assimilation, and decreased triglyceride percentage in Caenorhabditis elegans. Furthermore, the lactobacilli oral administration to obese mice caused a significant decrease in body weight gain and ameliorated hyperglycemia and hyperlipemia. These results reveal the potential of this goat dairy product as a functional food to prevent obesity and related pathologies. Goat milk-derived products stand out for their marketing potential. Hence, fermented goat milk incorporating novel probiotics represents a group of food products with broad prospects by their promising nutritive and therapeutic properties for metabolic diseases. The goat dairy product designed in this study could be used in the prevention of dyslipidemia and hyperglycemia in obese people. |
format | Online Article Text |
id | pubmed-9459688 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94596882022-09-10 Characterization of autochthonous lactobacilli from goat dairy products with probiotic potential for metabolic diseases Marquez, Antonela Andrada, Estefanía Russo, Matias Bolondi, María Lujan Fabersani, Emanuel Medina, Roxana Gauffin-Cano, Paola Heliyon Research Article The present study aimed to design functional fermented goat milk with probiotic potential for metabolic diseases. Thereby, autochthonous lactobacilli from goat dairy products that target improving the inflammatory, lipid, and glycemic profile were characterized. We designed fermented goat milk using Lactobacillus delbrueckii subsp. indicus CRL1447 as starter strain, supplemented with different probiotic consortia formed by Limosilactobacillus fermentum CRL1446, Lactiplantibacillus paraplantarum CRL1449, and CRL1472 strains. These lactobacilli were selected for their positive effects on inhibition of α-glucosidase, bile salts hydrolase activity, cholesterol assimilation, and decreased triglyceride percentage in Caenorhabditis elegans. Furthermore, the lactobacilli oral administration to obese mice caused a significant decrease in body weight gain and ameliorated hyperglycemia and hyperlipemia. These results reveal the potential of this goat dairy product as a functional food to prevent obesity and related pathologies. Goat milk-derived products stand out for their marketing potential. Hence, fermented goat milk incorporating novel probiotics represents a group of food products with broad prospects by their promising nutritive and therapeutic properties for metabolic diseases. The goat dairy product designed in this study could be used in the prevention of dyslipidemia and hyperglycemia in obese people. Elsevier 2022-08-28 /pmc/articles/PMC9459688/ /pubmed/36091951 http://dx.doi.org/10.1016/j.heliyon.2022.e10462 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Marquez, Antonela Andrada, Estefanía Russo, Matias Bolondi, María Lujan Fabersani, Emanuel Medina, Roxana Gauffin-Cano, Paola Characterization of autochthonous lactobacilli from goat dairy products with probiotic potential for metabolic diseases |
title | Characterization of autochthonous lactobacilli from goat dairy products with probiotic potential for metabolic diseases |
title_full | Characterization of autochthonous lactobacilli from goat dairy products with probiotic potential for metabolic diseases |
title_fullStr | Characterization of autochthonous lactobacilli from goat dairy products with probiotic potential for metabolic diseases |
title_full_unstemmed | Characterization of autochthonous lactobacilli from goat dairy products with probiotic potential for metabolic diseases |
title_short | Characterization of autochthonous lactobacilli from goat dairy products with probiotic potential for metabolic diseases |
title_sort | characterization of autochthonous lactobacilli from goat dairy products with probiotic potential for metabolic diseases |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459688/ https://www.ncbi.nlm.nih.gov/pubmed/36091951 http://dx.doi.org/10.1016/j.heliyon.2022.e10462 |
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