Constitutional BRCA1 Methylation and Risk of Incident Triple-Negative Breast Cancer and High-grade Serous Ovarian Cancer

IMPORTANCE: About 25% of all triple-negative breast cancers (TNBCs) and 10% to 20% of high-grade serous ovarian cancers (HGSOCs) harbor BRCA1 promoter methylation. While constitutional BRCA1 promoter methylation has been observed in normal tissues of some individuals, the potential role of normal ti...

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Detalles Bibliográficos
Autores principales: Lønning, Per E., Nikolaienko, Oleksii, Pan, Kathy, Kurian, Allison W., Eikesdal, Hans P., Pettinger, Mary, Anderson, Garnet L., Prentice, Ross L., Chlebowski, Rowan T., Knappskog, Stian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2022
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459895/
https://www.ncbi.nlm.nih.gov/pubmed/36074460
http://dx.doi.org/10.1001/jamaoncol.2022.3846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459895/
https://www.ncbi.nlm.nih.gov/pubmed/36074460
http://dx.doi.org/10.1001/jamaoncol.2022.3846

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