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Uncovering lipopolysaccharide regulation in bacteria via the critical lipid binding tunnel of YciS/YciM

Gram-negative bacteria contain an asymmetric outer membrane, in which the outer leaflet is composed of lipopolysaccharide (LPS). LPS, a drug target of polymyxin, plays an essential role in drug resistance, biofilm formation, and pathogenesis. An important inner membrane protein, YciM, may be respons...

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Detalles Bibliográficos
Autores principales: Yan, Lina, Dong, Haohao, Li, Huanyu, Liu, Xingyu, Deng, Zixin, Dong, Changjiang, Zhang, Zhengyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460159/
https://www.ncbi.nlm.nih.gov/pubmed/36093049
http://dx.doi.org/10.1016/j.isci.2022.104988