Ileal bile acid transporter inhibition in Cyp2c70 KO mice ameliorates cholestatic liver injury

Cyp2c70 is the liver enzyme in rodents responsible for synthesis of the primary 6-hydroxylated muricholate bile acid (BA) species. Cyp2c70 KO mice are devoid of protective, hydrophilic muricholic acids, leading to a more human-like BA composition and subsequent cholestatic liver injury. Pharmacologi...

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Detalles Bibliográficos
Autores principales: Truong, Jennifer K., Bennett, Ashley L., Klindt, Caroline, Donepudi, Ajay C., Malla, Sudarshan R., Pachura, Kimberly J., Zaufel, Alex, Moustafa, Tarek, Dawson, Paul A., Karpen, Saul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460185/
https://www.ncbi.nlm.nih.gov/pubmed/35934110
http://dx.doi.org/10.1016/j.jlr.2022.100261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460185/
https://www.ncbi.nlm.nih.gov/pubmed/35934110
http://dx.doi.org/10.1016/j.jlr.2022.100261

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