Striatal synaptic bioenergetic and autophagic decline in premotor experimental parkinsonism

Synaptic impairment might precede neuronal degeneration in Parkinson’s disease. However, the intimate mechanisms altering synaptic function by the accumulation of presynaptic α-synuclein in striatal dopaminergic terminals before dopaminergic death occurs, have not been elucidated. Our aim is to unra...

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Detalles Bibliográficos
Autores principales: Merino-Galán, Leyre, Jimenez-Urbieta, Haritz, Zamarbide, Marta, Rodríguez-Chinchilla, Tatiana, Belloso-Iguerategui, Arantzazu, Santamaria, Enrique, Fernández-Irigoyen, Joaquín, Aiastui, Ana, Doudnikoff, Evelyne, Bézard, Erwan, Ouro, Alberto, Knafo, Shira, Gago, Belén, Quiroga-Varela, Ana, Rodríguez-Oroz, María Cruz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460676/
https://www.ncbi.nlm.nih.gov/pubmed/35245368
http://dx.doi.org/10.1093/brain/awac087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460676/
https://www.ncbi.nlm.nih.gov/pubmed/35245368
http://dx.doi.org/10.1093/brain/awac087

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