Cargando…

Striatal synaptic bioenergetic and autophagic decline in premotor experimental parkinsonism

Synaptic impairment might precede neuronal degeneration in Parkinson’s disease. However, the intimate mechanisms altering synaptic function by the accumulation of presynaptic α-synuclein in striatal dopaminergic terminals before dopaminergic death occurs, have not been elucidated. Our aim is to unra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Merino-Galán, Leyre, Jimenez-Urbieta, Haritz, Zamarbide, Marta, Rodríguez-Chinchilla, Tatiana, Belloso-Iguerategui, Arantzazu, Santamaria, Enrique, Fernández-Irigoyen, Joaquín, Aiastui, Ana, Doudnikoff, Evelyne, Bézard, Erwan, Ouro, Alberto, Knafo, Shira, Gago, Belén, Quiroga-Varela, Ana, Rodríguez-Oroz, María Cruz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460676/ https://www.ncbi.nlm.nih.gov/pubmed/35245368 http://dx.doi.org/10.1093/brain/awac087

Ejemplares similares

Hippocampal synaptic failure is an early event in experimental parkinsonism with subtle cognitive deficit
por: Belloso-Iguerategui, Arantzazu, et al.
Publicado: (2023)

Transcriptomic integration of D(4)R and MOR signaling in the rat caudate putamen
por: Valderrama-Carvajal, Alejandra, et al.
Publicado: (2018)

EVOBREATH. Datasets for evolutionary bioenergetics research on anthropology
por: Mateos, Ana, et al.
Publicado: (2023)

Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy
por: Laferrière, Florent, et al.
Publicado: (2020)

Neglected premotor neglect
por: Saevarsson, Styrmir, et al.
Publicado: (2014)

Involvement of the bed nucleus of the stria terminalis in L-Dopa induced dyskinesia
por: Bastide, Matthieu F., et al.
Publicado: (2017)

Elemental gesture dynamics are encoded by song premotor cortical neurons
por: Amador, Ana, et al.
Publicado: (2013)

Rhythm and time in the premotor cortex
por: Penhune, Virginia B., et al.
Publicado: (2019)

FORTIS: a live-cell assay to monitor AMPA receptors using pH-sensitive fluorescence tags
por: Calleja-Felipe, María, et al.
Publicado: (2021)

Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology?
por: Charron, Giselle, et al.
Publicado: (2014)

Should Cell Culture Platforms Move towards EV Therapy Requirements?
por: Aiastui, Ana
Publicado: (2015)

Repurposing bioenergetic modulators against protozoan parasites responsible for tropical diseases
por: Martínez-Flórez, Alba, et al.
Publicado: (2020)

What Accounts for Physical Activity during Pregnancy? A Study on the Sociodemographic Predictors of Self-Reported and Objectively Assessed Physical Activity during the 1st and 2nd Trimesters of Pregnancy
por: Mendinueta, Ana, et al.
Publicado: (2020)

How Lazy Reading and Semantic Sloppiness May Harm Progress in Synucleinopathy Research
por: Bezard, Erwan
Publicado: (2022)

Premotor and Motor Cortices Encode Reward
por: Ramkumar, Pavan, et al.
Publicado: (2016)

Commentary: Injecting Instructions into Premotor Cortex
por: Lebedev, Mikhail A., et al.
Publicado: (2018)

Is there a Premotor Phase of Essential Tremor?
por: Lenka, Abhishek, et al.
Publicado: (2017)

The dynamics and geometry of choice in premotor cortex
por: Genkin, Mikhail, et al.
Publicado: (2023)

The Contribution of Premotor Cortico-Striatal Projections to the Execution of Serial Order Sequences
por: Sánchez-Fuentes, Asai, et al.
Publicado: (2021)

Striatal Proteomic Analysis Suggests that First L-Dopa Dose Equates to Chronic Exposure
por: Scholz, Birger, et al.
Publicado: (2008)

Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies
por: Arotcarena, Marie-Laure, et al.
Publicado: (2019)

Acidic nanoparticles protect against α‐synuclein‐induced neurodegeneration through the restoration of lysosomal function
por: Arotcarena, Marie‐Laure, et al.
Publicado: (2022)

Neuropsychiatric and Cognitive Deficits in Parkinson’s Disease and Their Modeling in Rodents
por: Decourt, Mélina, et al.
Publicado: (2021)

Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling
por: Soria, Federico N., et al.
Publicado: (2020)

Before the Tremor: Premotor Symptoms of Parkinson’s Disease
por: Konkel, Lindsey
Publicado: (2013)

Premotor cortex is critical for goal-directed actions
por: Gremel, Christina M., et al.
Publicado: (2013)

Structure and variability of delay activity in premotor cortex
por: Even-Chen, Nir, et al.
Publicado: (2019)

Functional redundancy of the premotor network in hemispherotomy patients
por: Prillwitz, Conrad C., et al.
Publicado: (2021)

Translational Model of Cortical Premotor-Motor Networks
por: Kreis, Svenja L, et al.
Publicado: (2021)

The role of habitual learning in premotor attention allocation
por: Topfstedt, Christof Elias, et al.
Publicado: (2023)

Spines, Plasticity, and Cognition in Alzheimer's Model Mice
por: Spires-Jones, Tara, et al.
Publicado: (2012)

Bioenergetics /
por: Lowen, Alexander
Publicado: (1975)

Differential serum microRNAs in premotor LRRK2 G2019S carriers from Parkinson’s disease
por: Soto, Marta, et al.
Publicado: (2023)

Decision-Making in the Ventral Premotor Cortex Harbinger of Action
por: Pardo-Vazquez, Jose L., et al.
Publicado: (2011)

Dorsal premotor cortex is involved in switching motor plans
por: Pastor-Bernier, Alexandre, et al.
Publicado: (2012)

Functional significance of the electrocorticographic auditory responses in the premotor cortex
por: Tanji, Kazuyo, et al.
Publicado: (2015)

The role of dorsal premotor cortex in joint action stopping
por: Cardellicchio, Pasquale, et al.
Publicado: (2021)

An abstract categorical decision code in dorsal premotor cortex
por: Diaz-deLeon, Gabriel, et al.
Publicado: (2022)

Basal Ganglia Circuits Underlying the Pathophysiology of Levodopa-Induced Dyskinesia
por: Barroso-Chinea, Pedro, et al.
Publicado: (2010)

Local transgene expression and whole‐body transgenesis to model brain diseases in nonhuman primate
por: Chansel‐Debordeaux, Lucie, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_oqdi2m6j7bt916blks4cktsqb4