Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer’s-induced retinal vasculopathy by limiting Clec7a/Galectin-3(+) neurodegenerative microglia

Single cell RNA sequencing studies identified novel neurodegeneration-associated microglial (MGnD/DAM) subtypes activated around cerebral amyloid plaques. Micro-RNA (miR)-155 of the TREM2-APOE pathway was shown to be a key transcriptional regulator of MGnD microglial phenotype. Despite growing inter...

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Detalles Bibliográficos
Autores principales: Shi, Haoshen, Yin, Zhuoran, Koronyo, Yosef, Fuchs, Dieu-Trang, Sheyn, Julia, Davis, Miyah R., Wilson, Jered W., Margeta, Milica A., Pitts, Kristen M., Herron, Shawn, Ikezu, Seiko, Ikezu, Tsuneya, Graham, Stuart L., Gupta, Vivek K., Black, Keith L., Mirzaei, Mehdi, Butovsky, Oleg, Koronyo-Hamaoui, Maya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461176/
https://www.ncbi.nlm.nih.gov/pubmed/36076283
http://dx.doi.org/10.1186/s40478-022-01439-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461176/
https://www.ncbi.nlm.nih.gov/pubmed/36076283
http://dx.doi.org/10.1186/s40478-022-01439-z

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