Recurrent noncoding somatic and germline WT1 variants converge to disrupt MYB binding in acute promyelocytic leukemia

Genetic alternations can occur at noncoding regions, but how they contribute to cancer pathogenesis is poorly understood. Here, we established a mutational landscape of cis-regulatory regions (CREs) in acute promyelocytic leukemia (APL) based on whole-genome sequencing analysis of paired tumor and g...

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Detalles Bibliográficos
Autores principales: Song, Huan, Liu, Yabin, Tan, Yun, Zhang, Yi, Jin, Wen, Chen, Li, Wu, Shishuang, Yan, Jinsong, Li, Junmin, Chen, Zhu, Chen, Saijuan, Wang, Kankan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461475/
https://www.ncbi.nlm.nih.gov/pubmed/35653587
http://dx.doi.org/10.1182/blood.2021014945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461475/
https://www.ncbi.nlm.nih.gov/pubmed/35653587
http://dx.doi.org/10.1182/blood.2021014945

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