Covalent Inhibition of Pyruvate Kinase M2 Reprograms Metabolic and Inflammatory Pathways in Hepatic Macrophages against Non-alcoholic Fatty Liver Disease

Warburg effect of aerobic glycolysis in hepatic M1 macrophages is a major cause for metabolic dysfunction and inflammatory stress in non-alcoholic fatty liver disease (NAFLD). Plant-derived triterpene celastrol markedly inhibited macrophage M1 polarization and adipocyte hypertrophy in obesity. The p...

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Detalles Bibliográficos
Autores principales: Fan, Ni, Zhang, Xiuying, Zhao, Wei, Zhao, Jia, Luo, Dan, Sun, Yilu, Li, Ding, Zhao, Chenliang, Wang, Yu, Zhang, Hongjie, Rong, Jianhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461663/
https://www.ncbi.nlm.nih.gov/pubmed/36147457
http://dx.doi.org/10.7150/ijbs.73890

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461663/
https://www.ncbi.nlm.nih.gov/pubmed/36147457
http://dx.doi.org/10.7150/ijbs.73890

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