Knockout and Double Knockout of Cathepsin K and Mmp9 reveals a novel function of Cathepsin K as a regulator of osteoclast gene expression and bone homeostasis

Cathepsins play a role in regulation of cell function through their presence in the cell nucleus. However, the role of Cathepsin K (Ctsk) as an epigenetic regulator in osteoclasts remains unknown. Our data demonstrated that Ctsk(-/-)Mmp9(-/-) mice have a striking phenotype with a 5-fold increase in...

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Detalles Bibliográficos
Autores principales: Zhu, Guochun, Chen, Wei, Tang, Chen-Yi, McVicar, Abigail, Edwards, Diep, Wang, Jinwen, McConnell, Matthew, Yang, Shuying, Li, Yang, Chang, Zhijie, Li, Yi-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461675/
https://www.ncbi.nlm.nih.gov/pubmed/36147479
http://dx.doi.org/10.7150/ijbs.72211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461675/
https://www.ncbi.nlm.nih.gov/pubmed/36147479
http://dx.doi.org/10.7150/ijbs.72211

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