Cargando…

Knockout and Double Knockout of Cathepsin K and Mmp9 reveals a novel function of Cathepsin K as a regulator of osteoclast gene expression and bone homeostasis

Cathepsins play a role in regulation of cell function through their presence in the cell nucleus. However, the role of Cathepsin K (Ctsk) as an epigenetic regulator in osteoclasts remains unknown. Our data demonstrated that Ctsk(-/-)Mmp9(-/-) mice have a striking phenotype with a 5-fold increase in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Guochun, Chen, Wei, Tang, Chen-Yi, McVicar, Abigail, Edwards, Diep, Wang, Jinwen, McConnell, Matthew, Yang, Shuying, Li, Yang, Chang, Zhijie, Li, Yi-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461675/ https://www.ncbi.nlm.nih.gov/pubmed/36147479 http://dx.doi.org/10.7150/ijbs.72211

Ejemplares similares

Cathepsin K knockout alleviates aging-induced cardiac dysfunction
por: Hua, Yinan, et al.
Publicado: (2015)

Cathepsin K knockout protects against cardiac dysfunction in diabetic mice
por: Guo, Rui, et al.
Publicado: (2017)

Cathepsin K Knockout Mitigates High-Fat Diet–Induced Cardiac Hypertrophy and Contractile Dysfunction
por: Hua, Yinan, et al.
Publicado: (2013)

Osteopenia Due to Enhanced Cathepsin K Release by BK Channel Ablation in Osteoclasts
por: Sausbier, Ulrike, et al.
Publicado: (2011)

Effects of the cathepsin K inhibitor with mineral trioxide aggregate cements on osteoclastic activity
por: Kim, Hee-Sun, et al.
Publicado: (2019)

Novel cathepsin K inhibitors block osteoclasts in vitro and increase spinal bone density in zebrafish
por: Xue, Si-tu, et al.
Publicado: (2019)

Cathepsin D overexpression in the nervous system rescues lethality and Aβ42 accumulation of cathepsin D systemic knockout in vivo
por: Ouyang, Xiaosen, et al.
Publicado: (2023)

Cathepsin K: The Action in and Beyond Bone
por: Dai, Rongchen, et al.
Publicado: (2020)

Cathepsin K(+) Non-Osteoclast Cells in the Skeletal System: Function, Models, Identity, and Therapeutic Implications
por: Zou, Nanyu, et al.
Publicado: (2022)

Nitrogen-Containing Bisphosphonates Downregulate Cathepsin K and Upregulate Annexin V in Osteoclasts Cultured In Vitro
por: Bautista-Carbajal, Arturo, et al.
Publicado: (2023)

Nicotine Affects Bone Resorption and Suppresses the Expression of Cathepsin K, MMP-9 and Vacuolar-Type H(+)-ATPase d2 and Actin Organization in Osteoclasts
por: Tanaka, Hideki, et al.
Publicado: (2013)

A protocol for visualizing active cathepsin K in osteoclasts with a quenched-fluorescence-activity-based probe
por: Korba, Aleksandra, et al.
Publicado: (2023)

Coronin 3 promotes gastric cancer metastasis via the up-regulation of MMP-9 and cathepsin K
por: Ren, Gui, et al.
Publicado: (2012)

Azanitrile Cathepsin K Inhibitors: Effects on Cell Toxicity, Osteoblast-Induced Mineralization and Osteoclast-Mediated Bone Resorption
por: Ren, Zhong-Yuan, et al.
Publicado: (2015)

Cathepsin K induces platelet dysfunction and affects cell signaling in breast cancer - molecularly distinct behavior of cathepsin K in breast cancer
por: Andrade, Sheila Siqueira, et al.
Publicado: (2016)

Inhibition of cathepsin K promotes osseointegration of titanium implants in ovariectomised rats
por: Yi, Chun, et al.
Publicado: (2017)

Matrix-metalloproteinase-9 is cleaved and activated by Cathepsin K
por: Christensen, Jon, et al.
Publicado: (2015)

Advances in the discovery of cathepsin K inhibitors on bone resorption
por: Lu, Jun, et al.
Publicado: (2018)

Cathepsin K Mutation—A Subtle Clinical Presentation
por: Nandipati, Venkata Sandeep, et al.
Publicado: (2022)

Serum and Synovial Levels of Cathepsin G and Cathepsin K in Patients with Psoriatic Arthritis and Their Correlation with Disease Activity Indices
por: Popova-Belova, Stanislava Dimitrova, et al.
Publicado: (2023)

Increased Serum Cathepsin K in Patients with Coronary Artery Disease
por: Li, Xiang, et al.
Publicado: (2014)

Correction: Coronin 3 promotes gastric cancer metastasis via the up-regulation of MMP-9 and cathepsin K
por: Ren, Gui, et al.
Publicado: (2022)

Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K
por: Ohmae, Saori, et al.
Publicado: (2017)

Increased Circulating Cathepsin K in Patients with Chronic Heart Failure
por: Zhao, Guangxian, et al.
Publicado: (2015)

Targeting cathepsin K diminishes prostate cancer establishment and growth in murine bone
por: Liang, Weiping, et al.
Publicado: (2019)

The Potential Role of Cathepsin K in Non-Small Cell Lung Cancer
por: Yang, Hui, et al.
Publicado: (2020)

The Expression and Activity of Cathepsins D, H and K in Asthmatic Airways
por: Faiz, Alen, et al.
Publicado: (2013)

Localization Patterns of Cathepsins K and X and their Predictive Value in Glioblastoma
por: Breznik, Barbara, et al.
Publicado: (2018)

Cathepsin K maintains the compartment of bone marrow T lymphocytes in vivo
por: Hausinger, Renate, et al.
Publicado: (2021)

Cathepsin K in Pathological Conditions and New Therapeutic and Diagnostic Perspectives
por: Mijanović, Olja, et al.
Publicado: (2022)

oxLDL inhibits differentiation and functional activity of osteoclasts via scavenger receptor-A mediated autophagy and cathepsin K secretion
por: Dawodu, Damilola, et al.
Publicado: (2018)

Cathepsins in digestive cancers
por: Chen, Siyuan, et al.
Publicado: (2017)

Do matrix metalloproteinase and cathepsin K inhibitors work synergistically to reduce dentin erosion?
por: LIN, Xiujiao, et al.
Publicado: (2023)

CD44 signalling increases cathepsin K and MT1MMP expression to potentiate breast cancer cell invasion through collagen I
por: Hill, A, et al.
Publicado: (2008)

THE ESTIMATION OF CATHEPSIN WITH HEMOGLOBIN AND THE PARTIAL PURIFICATION OF CATHEPSIN
por: Anson, M. L.
Publicado: (1937)

Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways
por: Tang, Chen-Yi, et al.
Publicado: (2021)

Correction: Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways
por: Tang, Chen-Yi, et al.
Publicado: (2022)

Osteoclasts’ Ability to Generate Trenches Rather Than Pits Depends on High Levels of Active Cathepsin K and Efficient Clearance of Resorption Products
por: Borggaard, Xenia G., et al.
Publicado: (2020)

Cathepsin K: A Versatile Potential Biomarker and Therapeutic Target for Various Cancers
por: Qian, Die, et al.
Publicado: (2022)

Cathepsin K-Cre Causes Unexpected Germline Deletion of Genes in Mice
por: Winkeler, Crystal L., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_cgu076113f133ecnlicf9ugq0u