Balanced engagement of activating and inhibitory receptors mitigates human NK cell exhaustion

NK cell exhaustion is caused by chronic exposure to activating stimuli during viral infection, tumorigenesis, and prolonged cytokine treatment. Evidence suggests that exhaustion may play a role in disease progression. However, relative to T cell exhaustion, the mechanisms underlying NK cell exhausti...

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Detalles Bibliográficos
Autores principales: Myers, Jacob A., Schirm, Dawn, Bendzick, Laura, Hopps, Rachel, Selleck, Carly, Hinderlie, Peter, Felices, Martin, Miller, Jeffrey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462468/
https://www.ncbi.nlm.nih.gov/pubmed/35727627
http://dx.doi.org/10.1172/jci.insight.150079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462468/
https://www.ncbi.nlm.nih.gov/pubmed/35727627
http://dx.doi.org/10.1172/jci.insight.150079

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