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Balanced engagement of activating and inhibitory receptors mitigates human NK cell exhaustion
NK cell exhaustion is caused by chronic exposure to activating stimuli during viral infection, tumorigenesis, and prolonged cytokine treatment. Evidence suggests that exhaustion may play a role in disease progression. However, relative to T cell exhaustion, the mechanisms underlying NK cell exhausti...
Autores principales: | Myers, Jacob A., Schirm, Dawn, Bendzick, Laura, Hopps, Rachel, Selleck, Carly, Hinderlie, Peter, Felices, Martin, Miller, Jeffrey S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462468/ https://www.ncbi.nlm.nih.gov/pubmed/35727627 http://dx.doi.org/10.1172/jci.insight.150079 |
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