Targeting gliovascular connexins prevents inflammatory blood-brain barrier leakage and astrogliosis

The blood-brain barrier is formed by capillary endothelial cells expressing connexin 37 (Cx37), Cx40, and Cx43 and is joined by closely apposed astrocytes expressing Cx43 and Cx30. We investigated whether connexin-targeting peptides could limit barrier leakage triggered by LPS-induced systemic infla...

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Detalles Bibliográficos
Autores principales: De Bock, Marijke, De Smet, Maarten, Verwaerde, Stijn, Tahiri, Hanane, Schumacher, Steffi, Van Haver, Valérie, Witschas, Katja, Steinhäuser, Christian, Rouach, Nathalie, Vandenbroucke, Roosmarijn E., Leybaert, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462469/
https://www.ncbi.nlm.nih.gov/pubmed/35881483
http://dx.doi.org/10.1172/jci.insight.135263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462469/
https://www.ncbi.nlm.nih.gov/pubmed/35881483
http://dx.doi.org/10.1172/jci.insight.135263

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