Dynamin-2 reduction rescues the skeletal myopathy of a SPEG-deficient mouse model

Striated preferentially expressed protein kinase (SPEG), a myosin light chain kinase, is mutated in centronuclear myopathy (CNM) and/or dilated cardiomyopathy. No precise therapies are available for this disorder, and gene replacement therapy is not a feasible option due to the large size of SPEG. W...

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Detalles Bibliográficos
Autores principales: Li, Qifei, Lin, Jasmine, Widrick, Jeffrey J., Luo, Shiyu, Li, Gu, Zhang, Yuanfan, Laporte, Jocelyn, Perrella, Mark A., Liu, Xiaoli, Agrawal, Pankaj B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462472/
https://www.ncbi.nlm.nih.gov/pubmed/35763354
http://dx.doi.org/10.1172/jci.insight.157336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462472/
https://www.ncbi.nlm.nih.gov/pubmed/35763354
http://dx.doi.org/10.1172/jci.insight.157336

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