Pharmacological induction of AMFR increases functional EAAT2 oligomer levels and reduces epileptic seizures in mice

Dysregulation of excitatory amino acid transporter 2 (EAAT2) contributes to the development of temporal lobe epilepsy (TLE). Several strategies for increasing total EAAT2 levels have been proposed. However, the mechanism underlying the oligomeric assembly of EAAT2, impairment of which inhibits the f...

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Detalles Bibliográficos
Autores principales: Sha, Longze, Li, Guanjun, Zhang, Xiuneng, Lin, Yarong, Qiu, Yunjie, Deng, Yu, Zhu, Wanwan, Xu, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462477/
https://www.ncbi.nlm.nih.gov/pubmed/35938532
http://dx.doi.org/10.1172/jci.insight.160247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462477/
https://www.ncbi.nlm.nih.gov/pubmed/35938532
http://dx.doi.org/10.1172/jci.insight.160247

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