ARMC5-CUL3 E3 ligase targets full-length SREBF in adrenocortical tumors

Inactivating mutations of ARMC5 are responsible for the development of bilateral macronodular adrenal hyperplasia (BMAH). Although ARMC5 inhibits adrenocortical tumor growth and is considered a tumor-suppressor gene, its molecular function is poorly understood. In this study, through biochemical pur...

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Detalles Bibliográficos
Autores principales: Okuno, Yosuke, Fukuhara, Atsunori, Otsuki, Michio, Shimomura, Iichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462479/
https://www.ncbi.nlm.nih.gov/pubmed/35862218
http://dx.doi.org/10.1172/jci.insight.151390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462479/
https://www.ncbi.nlm.nih.gov/pubmed/35862218
http://dx.doi.org/10.1172/jci.insight.151390

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