Integrated single-cell transcriptomics and proteomics reveal cellular-specific responses and microenvironment remodeling in aristolochic acid nephropathy

Aristolochic acid nephropathy (AAN) is characterized by acute proximal tubule necrosis and immune cell infiltration, contributing to the global burden of chronic kidney disease and urothelial cancer. Although the proximal tubule has been defined as the primary target of aristolochic acids I (AAI), t...

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Detalles Bibliográficos
Autores principales: Chen, Jiayun, Luo, Piao, Wang, Chen, Yang, Chuanbin, Bai, Yunmeng, He, Xueling, Zhang, Qian, Zhang, Junzhe, Yang, Jing, Wang, Shuang, Wang, Jigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462482/
https://www.ncbi.nlm.nih.gov/pubmed/35852860
http://dx.doi.org/10.1172/jci.insight.157360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462482/
https://www.ncbi.nlm.nih.gov/pubmed/35852860
http://dx.doi.org/10.1172/jci.insight.157360

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