Cargando…

Integrated single-cell transcriptomics and proteomics reveal cellular-specific responses and microenvironment remodeling in aristolochic acid nephropathy

Aristolochic acid nephropathy (AAN) is characterized by acute proximal tubule necrosis and immune cell infiltration, contributing to the global burden of chronic kidney disease and urothelial cancer. Although the proximal tubule has been defined as the primary target of aristolochic acids I (AAI), t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Jiayun, Luo, Piao, Wang, Chen, Yang, Chuanbin, Bai, Yunmeng, He, Xueling, Zhang, Qian, Zhang, Junzhe, Yang, Jing, Wang, Shuang, Wang, Jigang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462482/ https://www.ncbi.nlm.nih.gov/pubmed/35852860 http://dx.doi.org/10.1172/jci.insight.157360

Ejemplares similares

Dissection of cellular and molecular mechanisms of aristolochic acid-induced hepatotoxicity via single-cell transcriptomics
por: Luo, Piao, et al.
Publicado: (2022)

Dissection of Targeting Molecular Mechanisms of Aristolochic Acid-induced Nephrotoxicity via a Combined Deconvolution Strategy of Chemoproteomics and Metabolomics
por: Zhang, Qian, et al.
Publicado: (2022)

Overview of aristolochic acid nephropathy: an update
por: Zhou, Qingqing, et al.
Publicado: (2023)

Update of aristolochic acid nephropathy in Korea
por: Ban, Tae Hyun, et al.
Publicado: (2018)

Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid Nephropathy
por: Tseng, Chiao-Shih, et al.
Publicado: (2011)

18beta-glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs
por: Zhang, Qian, et al.
Publicado: (2022)

Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1
por: Luo, Piao, et al.
Publicado: (2022)

Single-cell transcriptome analysis reveals the regulatory effects of artesunate on splenic immune cells in polymicrobial sepsis
por: Chen, Jiayun, et al.
Publicado: (2023)

An Integrated View of Aristolochic Acid Nephropathy: Update of the Literature
por: Jadot, Inès, et al.
Publicado: (2017)

Integrative microRNA and mRNA expression profiling in acute aristolochic acid nephropathy in mice
por: Zhu, Ziqiang, et al.
Publicado: (2020)

Arterial Stiffness in Balkan Endemic Nephropathy, an Environmental Form of Aristolochic Acid Nephropathy
por: Premužić, Vedran, et al.
Publicado: (2018)

Effects of aristolochic acid I and/or hypokalemia on tubular damage in C57BL/6 rat with aristolochic acid nephropathy
por: Yi, Joo-Hark, et al.
Publicado: (2018)

«Suspects» in Etiology of Endemic Nephropathy: Aristolochic Acid versus Mycotoxins
por: Pepeljnjak, Stjepan, et al.
Publicado: (2010)

Blockade of the mTOR signaling pathway with rapamycin ameliorates aristolochic acid nephropathy
por: Wu, Minmin, et al.
Publicado: (2020)

Rapamycin protects against aristolochic acid nephropathy in mice by potentiating mammalian target of rapamycin-mediated autophagy
por: Lin, Fan, et al.
Publicado: (2021)

Targeting c-fms kinase attenuates chronic aristolochic acid nephropathy in mice
por: Dai, Xiao Y., et al.
Publicado: (2016)

Smad7 protects against chronic aristolochic acid nephropathy in mice
por: Dai, Xiao-Yu, et al.
Publicado: (2015)

Protective Effects of Melatonin Against Aristolochic Acid-Induced Nephropathy in Mice
por: Kim, Jung-Yeon, et al.
Publicado: (2019)

Growing risk of aristolochic acid nephropathy in the era of COVID-19 – Correspondence
por: Das, Tuyelee, et al.
Publicado: (2022)

Interleukin-22 Attenuated Renal Tubular Injury in Aristolochic Acid Nephropathy via Suppressing Activation of NLRP3 Inflammasome
por: Wang, Shaofei, et al.
Publicado: (2019)

Aristolochic acid nephropathy: A scientometric analysis of literature published from 1971 to 2019
por: Ji, Hongjian, et al.
Publicado: (2021)

Ultrasound enhances the therapeutic potential of mesenchymal stem cells wrapped in greater omentum for aristolochic acid nephropathy
por: Yang, Yuanjun, et al.
Publicado: (2021)

Tissue xanthine oxidoreductase activity in a mouse model of aristolochic acid nephropathy
por: Ishii, Takeo, et al.
Publicado: (2021)

Lycopene attenuates the inflammation and apoptosis in aristolochic acid nephropathy by targeting the Nrf2 antioxidant system
por: Wang, Yu, et al.
Publicado: (2022)

Bioinformatics facilitating the use of microarrays to delineate potential miRNA biomarkers in aristolochic acid nephropathy
por: Lv, Yana, et al.
Publicado: (2016)

Renal Protective Effects of 17β-Estradiol on Mice with Acute Aristolochic Acid Nephropathy
por: Shi, Min, et al.
Publicado: (2016)

Experimental Aristolochic Acid Nephropathy: A Relevant Model to Study AKI-to-CKD Transition
por: Baudoux, Thomas, et al.
Publicado: (2022)

Clinicopathologic characteristics and prognosis of upper tract urothelial carcinoma complicated with aristolochic acid nephropathy after radical nephroureterectomy
por: Shan, Hongli, et al.
Publicado: (2020)

Macrophage interferon regulatory factor 4 deletion ameliorates aristolochic acid nephropathy via reduced migration and increased apoptosis
por: Sasaki, Kensuke, et al.
Publicado: (2022)

Effect of prednisolone on glyoxalase 1 in an inbred mouse model of aristolochic acid nephropathy using a proteomics method with fluorogenic derivatization-liquid chromatography-tandem mass spectrometry
por: Chen, Shih‐Ming, et al.
Publicado: (2020)

A single‐cell atlas of bisphenol A (BPA)‐induced testicular injury in mice
por: Xia, Siyu, et al.
Publicado: (2022)

Mesenchymal Stem Cell Derived Extracellular Vesicles Ameliorate Kidney Injury in Aristolochic Acid Nephropathy
por: Kholia, Sharad, et al.
Publicado: (2020)

Renal angiotensin I-converting enzyme-deficient mice are protected against aristolochic acid nephropathy
por: Juretzko, Annett, et al.
Publicado: (2022)

Aristolochic acids exposure was not the main cause of liver tumorigenesis in adulthood
por: Chen, Shuzhen, et al.
Publicado: (2022)

Comparative Analysis of Aristolochic Acids in Aristolochia Medicinal Herbs and Evaluation of Their Toxicities
por: Zhang, Shu-Han, et al.
Publicado: (2022)

Aristolochic acid I exposure decreases oocyte quality
por: Li, Weidong, et al.
Publicado: (2022)

Aristolochic Acid-Induced Genotoxicity and Toxicogenomic Changes in Rodents
por: Li, Xi-Lin, et al.
Publicado: (2020)

Metabolomics analysis reveals the association between lipid abnormalities and oxidative stress, inflammation, fibrosis, and Nrf2 dysfunction in aristolochic acid-induced nephropathy
por: Zhao, Ying-Yong, et al.
Publicado: (2015)

Aristolochic Acid and Immunotherapy for Urothelial Carcinoma: Directions for unmet Needs
por: Yang, Huang-Yu, et al.
Publicado: (2019)

Dahuang Fuzi Decoction Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in Chronic Aristolochic Acid Nephropathy
por: Shui, Guang-xing, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_n47mqu7abnm4r0p04dasdsp6fs