Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity

Hepatic de novo lipogenesis is influenced by the branched-chain α-keto acid dehydrogenase (BCKDH) kinase (BCKDK). Here, we aimed to determine whether circulating levels of the immediate substrates of BCKDH, the branched-chain α-keto acids (BCKAs), and hepatic BCKDK expression are associated with the...

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Detalles Bibliográficos
Autores principales: Grenier-Larouche, Thomas, Coulter Kwee, Lydia, Deleye, Yann, Leon-Mimila, Paola, Walejko, Jacquelyn M., McGarrah, Robert W., Marceau, Simon, Trahan, Sylvain, Racine, Christine, Carpentier, André C., Lusis, Aldons J., Ilkayeva, Olga, Vohl, Marie-Claude, Huertas-Vazquez, Adriana, Tchernof, André, Shah, Svati H., Newgard, Christopher B., White, Phillip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462486/
https://www.ncbi.nlm.nih.gov/pubmed/35797133
http://dx.doi.org/10.1172/jci.insight.159204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462486/
https://www.ncbi.nlm.nih.gov/pubmed/35797133
http://dx.doi.org/10.1172/jci.insight.159204

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